DegronMD

Uniprot ID: Q15653

Source protein: NF-kappa-B inhibitor beta

Source gene: NFKBIB

Class: DEG_SCF_TRCP1_1

Location: 18:23

E3 ligase: BTRC

DEGRON score: 0.9958

ASA_SCORE: 39.3167

COIL: 0.8363

CONS_SCORE: 0.5726

DSS_SCORE: 0.371

HELIX: 0.1193

FCONS_SCORE: 1.04

RIG_SCORE: 0.7122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R25W	DO230334	COCA	ICGC	DSGLGS	DEG_SCF_TRCP1_1	0.2778
p.R13L	DO229034	LICA	ICGC	DSGLGS	DEG_SCF_TRCP1_1	0.1944
p.W23L	DO229045	LICA	ICGC	DSGLGS	DEG_SCF_TRCP1_1	0.7015
p.S26I	DO50671	ORCA	ICGC	DSGLGS	DEG_SCF_TRCP1_1	0.25
p.W16R	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGLGS	DEG_SCF_TRCP1_1	0.2778
p.T23M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLGS	DEG_SCF_TRCP1_1	0.8534

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15653	NF-kappa-B inhibitor beta	DEG_SCF_TRCP1_1	18:23	DSGLGS	BTRC	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons