DegronMD - Q15697(ZNF174)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G228R	TCGA-13-0903	OV	TCGA	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1389
p.G228R	DO32616	OV	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1389
p.G228E	TCGA-13-0903	OV	TCGA	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1389
p.G228E	DO32616	OV	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1389
p.G207W	TCGA-D3-A2JG	SKCM	TCGA	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.0556
p.G207W	DO47613	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.0556
p.G207E	TCGA-EE-A2A2	SKCM	TCGA	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.0556
p.G207E	DO37583	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.0556
p.L218V	DO51865	BLCA	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation altering degron motif	0.6765
p.M229I	DO229022	LICA	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1111
p.A226D	DO229054	LICA	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1944
p.S220N	DO227725	PBCA	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation altering degron motif	0.7069
p.P221L	DO37679	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation altering degron motif	0.6471
p.P225L	DO37446	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.K214R	DO52402	UCEC	ICGC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.25
p.P221R	SIDM00858	Osteosarcoma	GDSC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation altering degron motif	0.6401
p.P221R	G-292_Clone_A141B1	bone	COSMIC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation altering degron motif	0.6401
p.G225R	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.G225R	ACH-000727	Lung Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.G225R	NCI-H2066	lung	COSMIC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.G225V	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.G225V	ACH-000727	Lung Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.G225V	NCI-H2066	lung	COSMIC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.2222
p.P231S	ACH-001991	Primary	CCLE	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.0556
p.K210T	SK-GT-4	oesophagus	COSMIC	NKENP	DEG_APCC_KENBOX_2	217:221	Mutation rewiring degron network	0.1389

Kaplan plot for ZNF174 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF174

UniProt ID: Q15697

Entrez ID: 7727

Protein name: Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF174 in