DegronMD

Uniprot ID: Q15697

Source protein: Zinc finger protein 174

Source gene: ZNF174

Class: DEG_APCC_KENBOX_2

Location: 217:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9505

ASA_SCORE: 105.42

COIL: 0.8628

CONS_SCORE: 0.579

DSS_SCORE: 0.8083

HELIX: 0.1262

FCONS_SCORE: 1.013

RIG_SCORE: 0.5995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G228R	TCGA-13-0903	OV	TCGA	NKENP	DEG_APCC_KENBOX_2	0.1389
p.G228R	DO32616	OV	ICGC	NKENP	DEG_APCC_KENBOX_2	0.1389
p.G228E	TCGA-13-0903	OV	TCGA	NKENP	DEG_APCC_KENBOX_2	0.1389
p.G228E	DO32616	OV	ICGC	NKENP	DEG_APCC_KENBOX_2	0.1389
p.G207W	TCGA-D3-A2JG	SKCM	TCGA	NKENP	DEG_APCC_KENBOX_2	0.0556
p.G207W	DO47613	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	0.0556
p.G207E	TCGA-EE-A2A2	SKCM	TCGA	NKENP	DEG_APCC_KENBOX_2	0.0556
p.G207E	DO37583	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	0.0556
p.L218V	DO51865	BLCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6765
p.M229I	DO229022	LICA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.1111
p.A226D	DO229054	LICA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.1944
p.S220N	DO227725	PBCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.7069
p.P221L	DO37679	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6471
p.P225L	DO37446	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	0.2222
p.K214R	DO52402	UCEC	ICGC	NKENP	DEG_APCC_KENBOX_2	0.25
p.P221R	SIDM00858	Osteosarcoma	GDSC	NKENP	DEG_APCC_KENBOX_2	0.6401
p.P221R	G-292_Clone_A141B1	bone	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.6401
p.G225R	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	NKENP	DEG_APCC_KENBOX_2	0.2222
p.G225R	ACH-000727	Lung Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	0.2222
p.G225R	NCI-H2066	lung	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.2222
p.G225V	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	NKENP	DEG_APCC_KENBOX_2	0.2222
p.G225V	ACH-000727	Lung Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	0.2222
p.G225V	NCI-H2066	lung	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.2222
p.P231S	ACH-001991	Primary	CCLE	NKENP	DEG_APCC_KENBOX_2	0.0556
p.K210T	SK-GT-4	oesophagus	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons