DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_APCC_KENBOX_2

Location: 1135:1139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 120.88

COIL: 0.9166

CONS_SCORE: 0.4034

DSS_SCORE: 0.7025

HELIX: 0.0496

FCONS_SCORE: 1.2242

RIG_SCORE: 0.641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1144L	TCGA-BF-AAP4	SKCM	TCGA	NKENP	DEG_APCC_KENBOX_2	0.1944
p.E1131Q	TCGA-Q1-A73P	CESC	TCGA	NKENP	DEG_APCC_KENBOX_2	0.2222
p.R1137W	TCGA-UY-A9PE	BLCA	TCGA	NKENP	DEG_APCC_KENBOX_2	0.8634
p.R1137W	SIDM00142	Endometrial Carcinoma	GDSC	NKENP	DEG_APCC_KENBOX_2	0.8634
p.R1137W	ACH-000864	Endometrial/Uterine Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	0.8634
p.R1137W	COLO-684	endometrium	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.8634
p.R1132W	DO219043	BLCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.25
p.R1132W	DO223378	CLLE	ICGC	NKENP	DEG_APCC_KENBOX_2	0.25
p.R1132W	ACH-001042	Ovarian Cancer	CCLE	NKENP	DEG_APCC_KENBOX_2	0.25
p.R1132W	COLO-684	endometrium	COSMIC	NKENP	DEG_APCC_KENBOX_2	0.25
p.K1136Q	DO228471	BRCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO229013	COCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO229016	COCA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO229489	LAML	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO230659	LAML	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO231140	LAML	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.K1136Q	DO229047	LICA	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6944
p.E1126Q	DO49983	CESC	ICGC	NKENP	DEG_APCC_KENBOX_2	0.0833
p.E1145K	DO218935	LUAD	ICGC	NKENP	DEG_APCC_KENBOX_2	0.1667
p.P1139L	DO219468	SKCM	ICGC	NKENP	DEG_APCC_KENBOX_2	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons