DegronMD - Q15738(NSDHL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y92H	TCGA-2W-A8YY	CESC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.1667
p.Y92H	DO223732	CESC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.1667
p.Q77H	TCGA-97-7546	LUAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.3056
p.Q77H	DO23762	LUAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.3056
p.R79W	TCGA-AP-A051	UCEC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.8634
p.R79W	DO232224	PBCA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.8634
p.R79W	DO42673	UCEC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.8634
p.L85I	TCGA-AP-A059	UCEC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.6063
p.L85I	DO41361	UCEC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.6063
p.N75K	TCGA-BR-6452	STAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.25
p.N75K	DO38404	STAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.25
p.D68H	TCGA-C5-A2LS	CESC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.0556
p.D68H	DO49879	CESC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.0556
p.L85H	TCGA-CK-4951	COAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.7313
p.L85H	DO10582	COAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.7313
p.R88Q	TCGA-OL-A5S0	BRCA	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.2778
p.R88Q	DO44155	BRCA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation rewiring degron network	0.2778
p.C86F	DO229029	LICA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.5996
p.F80L	ACH-000993	Endometrial/Uterine Cancer	CCLE	VRFFLGDLC	DEG_APCC_DBOX_1	78:86	Mutation altering degron motif	0.587

Kaplan plot for NSDHL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSDHL

UniProt ID: Q15738

Entrez ID: 50814

Protein name: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSDHL in