DegronMD

Uniprot ID: Q15738

Source protein: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Source gene: NSDHL

Class: DEG_APCC_DBOX_1

Location: 78:86

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6839

ASA_SCORE: 31.6333

COIL: 0.4398

CONS_SCORE: 0.525

DSS_SCORE: 0.0983

HELIX: 0.0211

FCONS_SCORE: 1.281

RIG_SCORE: 0.9145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y92H	TCGA-2W-A8YY	CESC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.1667
p.Y92H	DO223732	CESC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.1667
p.Q77H	TCGA-97-7546	LUAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.3056
p.Q77H	DO23762	LUAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.3056
p.R79W	TCGA-AP-A051	UCEC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.8634
p.R79W	DO232224	PBCA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.8634
p.R79W	DO42673	UCEC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.8634
p.L85I	TCGA-AP-A059	UCEC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.6063
p.L85I	DO41361	UCEC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.6063
p.N75K	TCGA-BR-6452	STAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.25
p.N75K	DO38404	STAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.25
p.D68H	TCGA-C5-A2LS	CESC	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.0556
p.D68H	DO49879	CESC	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.0556
p.L85H	TCGA-CK-4951	COAD	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.7313
p.L85H	DO10582	COAD	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.7313
p.R88Q	TCGA-OL-A5S0	BRCA	TCGA	VRFFLGDLC	DEG_APCC_DBOX_1	0.2778
p.R88Q	DO44155	BRCA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.2778
p.C86F	DO229029	LICA	ICGC	VRFFLGDLC	DEG_APCC_DBOX_1	0.5996
p.F80L	ACH-000993	Endometrial/Uterine Cancer	CCLE	VRFFLGDLC	DEG_APCC_DBOX_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15738	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	DEG_APCC_DBOX_1	78:86	VRFFLGDLC	APC,CDC20,FZR1	0.6839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons