DegronMD - Q15785(TOMM34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A131S	TCGA-A5-A0G1	UCEC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.A131S	DO42472	UCEC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.0833
p.D134E	TCGA-A5-A0G2	UCEC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1667
p.D134E	DO41235	UCEC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.1667
p.R141L	TCGA-AA-3697	COAD	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8428
p.R141L	DO8424	COAD	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8428
p.S146L	TCGA-BT-A3PJ	BLCA	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.7667
p.S146L	DO44097	BLCA	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.7667
p.P145H	TCGA-D3-A1QA	SKCM	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.6583
p.P145H	DO47469	SKCM	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.6583
p.R141C	TCGA-DU-6392	LGG	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8301
p.R141C	DO22237	LGG	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8301
p.E139Q	TCGA-Q1-A73O	CESC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.3056
p.E139Q	DO51612	CESC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.3056
p.I147V	SIDM00487	Colorectal Carcinoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.5965
p.I147V	CCK-81	large intestine	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.5965
p.R141H	SIDM01101	Neuroblastoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8244
p.R141H	ACH-000260	Neuroblastoma	CCLE	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8244
p.R141H	SK-N-AS	autonomic ganglia	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation altering degron motif	0.8244
p.P151S	SIDM00980	Gastric Carcinoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.25
p.P151S	ACH-000948	Gastric Cancer	CCLE	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.25
p.P151S	23132-87	stomach	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	140:148	Mutation rewiring degron network	0.25

Kaplan plot for TOMM34 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOMM34

UniProt ID: Q15785

Entrez ID: 10953

Protein name: Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOMM34 in