DegronMD

Uniprot ID: Q15785

Source protein: Mitochondrial import receptor subunit TOM34

Source gene: TOMM34

Class: DEG_APCC_DBOX_1

Location: 140:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9922

ASA_SCORE: 64.5

COIL: 0.6743

CONS_SCORE: 0.2796

DSS_SCORE: 0.2671

HELIX: 0.2951

FCONS_SCORE: 1.0975

RIG_SCORE: 0.7947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A131S	TCGA-A5-A0G1	UCEC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.0833
p.A131S	DO42472	UCEC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.0833
p.D134E	TCGA-A5-A0G2	UCEC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.1667
p.D134E	DO41235	UCEC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.1667
p.R141L	TCGA-AA-3697	COAD	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.8428
p.R141L	DO8424	COAD	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.8428
p.S146L	TCGA-BT-A3PJ	BLCA	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.7667
p.S146L	DO44097	BLCA	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.7667
p.P145H	TCGA-D3-A1QA	SKCM	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.6583
p.P145H	DO47469	SKCM	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.6583
p.R141C	TCGA-DU-6392	LGG	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.8301
p.R141C	DO22237	LGG	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.8301
p.E139Q	TCGA-Q1-A73O	CESC	TCGA	WRLKLPSIP	DEG_APCC_DBOX_1	0.3056
p.E139Q	DO51612	CESC	ICGC	WRLKLPSIP	DEG_APCC_DBOX_1	0.3056
p.I147V	SIDM00487	Colorectal Carcinoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	0.5965
p.I147V	CCK-81	large_intestine	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	0.5965
p.R141H	SIDM01101	Neuroblastoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	0.8244
p.R141H	ACH-000260	Neuroblastoma	CCLE	WRLKLPSIP	DEG_APCC_DBOX_1	0.8244
p.R141H	SK-N-AS	autonomic_ganglia	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	0.8244
p.P151S	SIDM00980	Gastric Carcinoma	GDSC	WRLKLPSIP	DEG_APCC_DBOX_1	0.25
p.P151S	ACH-000948	Gastric Cancer	CCLE	WRLKLPSIP	DEG_APCC_DBOX_1	0.25
p.P151S	23132-87	stomach	COSMIC	WRLKLPSIP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15785	Mitochondrial import receptor subunit TOM34	DEG_APCC_DBOX_1	140:148	WRLKLPSIP	APC,CDC20,FZR1	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons