DegronMD - Q15818(NPTX1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S113L	TCGA-BR-7958	STAD	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1111
p.S113L	DO38344	STAD	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1111
p.G112S	TCGA-EE-A3AE	SKCM	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.0833
p.G112S	DO37802	SKCM	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.0833
p.Q135H	TCGA-UD-AAC4	MESO	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1389
p.G112D	DO220899	MELA	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.0833
p.G134R	ACH-001690	Head and Neck Cancer	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.1667
p.L121P	ACH-001863	Bile Duct Cancer	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation altering degron motif	0.6471
p.Q132E	ACH-002055	Lymphoma	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	121:128	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons