DegronMD

Uniprot ID: Q15818

Source protein: Neuronal pentraxin-1

Source gene: NPTX1

Class: DEG_SCF_FBW7_2

Location: 121:128

E3 ligase: FBXW7

DEGRON score: 0.9678

ASA_SCORE: 78.8875

COIL: 0.5928

CONS_SCORE: 0.7994

DSS_SCORE: 0.6353

HELIX: 0.3776

FCONS_SCORE: 0.9895

RIG_SCORE: 0.6989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S113L	TCGA-BR-7958	STAD	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	0.1111
p.S113L	DO38344	STAD	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	0.1111
p.G112S	TCGA-EE-A3AE	SKCM	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	0.0833
p.G112S	DO37802	SKCM	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	0.0833
p.Q135H	TCGA-UD-AAC4	MESO	TCGA	LSRTPAAE	DEG_SCF_FBW7_2	0.1389
p.G112D	DO220899	MELA	ICGC	LSRTPAAE	DEG_SCF_FBW7_2	0.0833
p.G134R	ACH-001690	Head and Neck Cancer	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	0.1667
p.L121P	ACH-001863	Bile Duct Cancer	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	0.6471
p.Q132E	ACH-002055	Lymphoma	CCLE	LSRTPAAE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15818	Neuronal pentraxin-1	DEG_SCF_FBW7_2	121:128	LSRTPAAE	FBXW7	0.9678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons