DegronMD - Q15848(ADIPOQ)

GO - Biological processes (BP): brown fat cell differentiation [GO:0050873]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to insulin stimulus [GO:0032869]; cellular response to xenobiotic stimulus [GO:0071466]; circadian rhythm [GO:0007623]; detection of oxidative stress [GO:0070994]; fatty acid beta-oxidation [GO:0006635]; fatty acid oxidation [GO:0019395]; gene expression [GO:0010467]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell migration [GO:0030336]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of hormone secretion [GO:0046888]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular protein transport [GO:0090317]; negative regulation of low-density lipoprotein receptor activity [GO:1905598]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metanephric mesenchymal cell migration [GO:2000590]; negative regulation of phagocytosis [GO:0050765]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of receptor binding [GO:1900121]; negative regulation of synaptic transmission [GO:0050805]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular associated smooth muscle cell proliferation [GO:1904706]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of lipid transporter activity [GO:0110113]; positive regulation of metanephric glomerular visceral epithelial cell development [GO:2000478]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of myeloid cell apoptotic process [GO:0033034]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of renal albumin absorption [GO:2000534]; positive regulation of signal transduction [GO:0009967]; protein localization to plasma membrane [GO:0072659]; regulation of glucose metabolic process [GO:0010906]; response to activity [GO:0014823]; response to bacterium [GO:0009617]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to linoleic acid [GO:0070543]; response to nutrient [GO:0007584]; response to sucrose [GO:0009744]; response to tumor necrosis factor [GO:0034612] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H241Y	TCGA-AP-A1DK	UCEC	TCGA	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6118
p.H241Y	DO42033	UCEC	ICGC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6118
p.D231V	SIDM00426	Rhabdomyosarcoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation rewiring degron network	0.1667
p.D231V	ACH-000100	Sarcoma	CCLE	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation rewiring degron network	0.1667
p.D231V	ACH-001765	Sarcoma	CCLE	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation rewiring degron network	0.1667
p.D231V	RH-41	soft tissue	COSMIC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation rewiring degron network	0.1667
p.H241P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.H241P	SIDM00024	Non-Cancerous	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.H241P	SIDM00997	Thyroid Gland Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.H241P	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.H241P	SIDM00233	T-Lymphoblastic Leukemia	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.H241P	SIDM01393	Gastric Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.6583
p.D242V	SIDM00596	Endometrial Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.7785
p.D242V	ACH-001517	Endometrial/Uterine Cancer	CCLE	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.7785
p.D242V	HEC-1	endometrium	COSMIC	FLLYHD	LIG_APCC_ABBA_1	237:242	Mutation altering degron motif	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADIPOQ

UniProt ID: Q15848

Entrez ID: 9370

Protein name: Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADIPOQ in