DegronMD

Uniprot ID: Q15848

Source protein: Adiponectin

Source gene: ADIPOQ

Class: LIG_APCC_ABBA_1

Location: 237:242

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5029

ASA_SCORE: 39.0333

COIL: 0.2922

CONS_SCORE: 0.7534

DSS_SCORE: 0.5949

HELIX: 0.0025

FCONS_SCORE: 1.0895

RIG_SCORE: 0.8497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H241Y	TCGA-AP-A1DK	UCEC	TCGA	FLLYHD	LIG_APCC_ABBA_1	0.6118
p.H241Y	DO42033	UCEC	ICGC	FLLYHD	LIG_APCC_ABBA_1	0.6118
p.D231V	SIDM00426	Rhabdomyosarcoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.1667
p.D231V	ACH-000100	Sarcoma	CCLE	FLLYHD	LIG_APCC_ABBA_1	0.1667
p.D231V	ACH-001765	Sarcoma	CCLE	FLLYHD	LIG_APCC_ABBA_1	0.1667
p.D231V	RH-41	soft_tissue	COSMIC	FLLYHD	LIG_APCC_ABBA_1	0.1667
p.H241P	SIDM01259	B-Lymphoblastic Leukemia	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.H241P	SIDM00024	Non-Cancerous	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.H241P	SIDM00997	Thyroid Gland Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.H241P	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.H241P	SIDM00233	T-Lymphoblastic Leukemia	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.H241P	SIDM01393	Gastric Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.6583
p.D242V	SIDM00596	Endometrial Carcinoma	GDSC	FLLYHD	LIG_APCC_ABBA_1	0.7785
p.D242V	ACH-001517	Endometrial/Uterine Cancer	CCLE	FLLYHD	LIG_APCC_ABBA_1	0.7785
p.D242V	HEC-1	endometrium	COSMIC	FLLYHD	LIG_APCC_ABBA_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15848	Adiponectin	LIG_APCC_ABBA_1	237:242	FLLYHD	APC,CDC20,FZR1	0.5029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons