DegronMD - Q15849(SLC14A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R476S	TCGA-3B-A9HO	SARC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476S	DO219929	SARC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476K	TCGA-A5-A0G2	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476K	DO41235	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.F493I	TCGA-AG-3891	READ	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.1389
p.F493I	DO36388	READ	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.1389
p.K495R	TCGA-AP-A051	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation blocking ubiquitination signal	0.5278
p.K495R	DO42673	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation blocking ubiquitination signal	0.5278
p.W483R	TCGA-AP-A059	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.8634
p.W483R	DO41361	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.8634
p.H480Y	TCGA-FW-A3R5	SKCM	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.6118
p.H480Y	DO37406	SKCM	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.6118
p.E469G	DO230309	COCA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.0556
p.R476M	DO233146	GACA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476M	DO229041	LICA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476M	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476M	ACH-000675	Lung Cancer	CCLE	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.R476M	NCI-H1734	lung	COSMIC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation rewiring degron network	0.25
p.W483L	DO229041	LICA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.7015
p.F479Y	DO229268	THCA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	479:486	Mutation altering degron motif	0.7528

Kaplan plot for SLC14A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC14A2

UniProt ID: Q15849

Entrez ID: 8170

Protein name: Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC14A2 in