DegronMD

Uniprot ID: Q15849

Source protein: Urea transporter 2

Source gene: SLC14A2

Class: DEG_MDM2_SWIB_1

Location: 479:486

E3 ligase: MDM2

DEGRON score: 0.9547

ASA_SCORE: 47.05

COIL: 0.2176

CONS_SCORE: 0.3966

DSS_SCORE: 0.3598

HELIX: 0.4914

FCONS_SCORE: 1.0591

RIG_SCORE: 0.8004

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W483R	TCGA-AP-A059	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.8634
p.W483R	DO41361	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.8634
p.F479Y	DO229268	THCA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.7528
p.W483L	DO229041	LICA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.7015
p.H480Y	TCGA-FW-A3R5	SKCM	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.6118
p.H480Y	DO37406	SKCM	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.6118
p.K495R	TCGA-AP-A051	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.5278
p.K495R	DO42673	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.5278
p.R476S	TCGA-3B-A9HO	SARC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476S	DO219929	SARC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476K	TCGA-A5-A0G2	UCEC	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476K	DO41235	UCEC	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476M	DO233146	GACA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476M	DO229041	LICA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476M	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476M	ACH-000675	Lung Cancer	CCLE	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.R476M	NCI-H1734	lung	COSMIC	FHIEWSSI	DEG_MDM2_SWIB_1	0.25
p.F493I	TCGA-AG-3891	READ	TCGA	FHIEWSSI	DEG_MDM2_SWIB_1	0.1389
p.F493I	DO36388	READ	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.1389
p.E469G	DO230309	COCA	ICGC	FHIEWSSI	DEG_MDM2_SWIB_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15849	Urea transporter 2	DEG_MDM2_SWIB_1	479:486	FHIEWSSI	MDM2	0.9547	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons