DegronMD - Q15878(CACNA1E)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2149S	TCGA-14-1453	GBM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.S2171Y	TCGA-21-1082	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111
p.S2145Y	TCGA-22-1012	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.T2151N	TCGA-33-4583	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.S2150R	TCGA-39-5034	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.S2150T	TCGA-66-2767	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.R2167W	TCGA-BG-A0VT	UCEC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.V2162I	TCGA-CR-6493	HNSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.5965
p.V2162I	TCGA-HC-7080	PRAD	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.5965
p.V2162I	TCGA-ZR-A9CJ	ESCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.5965
p.S2171F	TCGA-D9-A1JW	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111
p.S2145C	TCGA-DD-A4NQ	LIHC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.R2167Q	TCGA-E2-A108	BRCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.R2167Q	TCGA-FI-A2F4	UCEC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.S2173R	TCGA-E7-A4IJ	BLCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.0556
p.R2154K	TCGA-EE-A29L	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.3056
p.S2145F	TCGA-EE-A3AC	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.R2156C	TCGA-EI-6917	READ	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.8301
p.S2147C	TCGA-L6-A4EU	THCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111
p.R2157W	TCGA-NH-A5IV	COAD	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7523
p.R2157W	SIDM00118	Colorectal Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7523
p.R2157W	HCC2998	large intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7523
p.L2161R	DO219042	BLCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.8428
p.E2168K	DO222973	BTCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.E2168K	DO222599	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.E2168K	DO37835	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.E2168K	CL-11	large intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.R2173Q	DO10782	COAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.0556
p.G2145V	DO8264	COAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.G2156C	DO222755	COCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.76
p.R2164C	DO233161	GACA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.3056
p.P2171Q	DO15198	HNSC	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111
p.H2172Y	DO228907	LICA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.0833
p.R2162G	DO220866	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7568
p.G2145E	DO220875	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.G2145E	DO37635	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.G2145E	DO37839	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.G2145E	ACH-000762	Head and Neck Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation blocking phosphorylation signal	0.5
p.S2167F	DO222702	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.S2167F	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.S2161F	DO229446	SKCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7982
p.S2151F	DO37703	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.C2163R	DO47819	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.8301
p.S2151Y	DO47929	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.Q2155R	DO222392	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.7329
p.S2167Y	DO41133	UCEC	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.P2161H	SIDM00120	Prostate Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6583
p.P2161H	DU-145	prostate	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6583
p.R2157Q	SIDM01002	Breast Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6218
p.R2157Q	SIDM00265	Ewing's Sarcoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6218
p.R2157Q	SIDM00847	Rhabdomyosarcoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6218
p.Y2172C	SIDM00846	Cervical Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.0833
p.L2170F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1389
p.L2170F	ACH-000904	Lung Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1389
p.L2170F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1389
p.L2169I	SIDM01609	Endometrial Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.L2152M	ACH-000707	Lymphoma	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.25
p.L2152M	ACH-002252	Lymphoma	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.25
p.L2152M	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.25
p.N2169S	ACH-001568	Skin Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.N2169S	ACH-002159	Skin Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.N2169S	M14	skin	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.L2169F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1667
p.N2150S	M14	skin	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1944
p.S2146R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.0833
p.E2147K	DBTRG-05MG	central nervous system	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111
p.R2156W	HCC2998	large intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.8634
p.L2151F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.2222
p.S2170R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1389
p.P2160H	DU-145	prostate	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation altering degron motif	0.6583
p.E2171K	DBTRG-05MG	central nervous system	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	2155:2163	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1E

UniProt ID: Q15878

Entrez ID: 777

Protein name: Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CACNA1E in