DegronMD

Uniprot ID: Q15878

Source protein: Voltage-dependent R-type calcium channel subunit alpha-1E

Source gene: CACNA1E

Class: DEG_APCC_DBOX_1

Location: 2155:2163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9659

ASA_SCORE: 109.4778

COIL: 0.9516

CONS_SCORE: 0.2721

DSS_SCORE: 0.7856

HELIX: 0.0307

FCONS_SCORE: 0.9514

RIG_SCORE: 0.6173

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2149S	TCGA-14-1453	GBM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.S2171Y	TCGA-21-1082	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111
p.S2145Y	TCGA-22-1012	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.T2151N	TCGA-33-4583	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.S2150R	TCGA-39-5034	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.S2150T	TCGA-66-2767	LUSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.R2167W	TCGA-BG-A0VT	UCEC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.V2162I	TCGA-CR-6493	HNSC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5965
p.V2162I	TCGA-HC-7080	PRAD	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5965
p.V2162I	TCGA-ZR-A9CJ	ESCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5965
p.S2171F	TCGA-D9-A1JW	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111
p.S2145C	TCGA-DD-A4NQ	LIHC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.R2167Q	TCGA-E2-A108	BRCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.R2167Q	TCGA-FI-A2F4	UCEC	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.S2173R	TCGA-E7-A4IJ	BLCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.0556
p.R2154K	TCGA-EE-A29L	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.3056
p.S2145F	TCGA-EE-A3AC	SKCM	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.R2156C	TCGA-EI-6917	READ	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.8301
p.S2147C	TCGA-L6-A4EU	THCA	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111
p.R2157W	TCGA-NH-A5IV	COAD	TCGA	SRRQLPPVP	DEG_APCC_DBOX_1	0.7523
p.R2157W	SIDM00118	Colorectal Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.7523
p.R2157W	HCC2998	large_intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.7523
p.L2161R	DO219042	BLCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.8428
p.E2168K	DO222973	BTCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.E2168K	DO222599	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.E2168K	DO37835	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.E2168K	CL-11	large_intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.R2173Q	DO10782	COAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.0556
p.G2145V	DO8264	COAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.G2156C	DO222755	COCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.76
p.R2164C	DO233161	GACA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.3056
p.P2171Q	DO15198	HNSC	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111
p.H2172Y	DO228907	LICA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.0833
p.R2162G	DO220866	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.7568
p.G2145E	DO220875	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.G2145E	DO37635	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.G2145E	DO37839	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.G2145E	ACH-000762	Head and Neck Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.5
p.S2167F	DO222702	MELA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.S2167F	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.S2161F	DO229446	SKCA	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.7982
p.S2151F	DO37703	SKCM	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.C2163R	DO47819	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.8301
p.S2151Y	DO47929	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.Q2155R	DO222392	STAD	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.7329
p.S2167Y	DO41133	UCEC	ICGC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.P2161H	SIDM00120	Prostate Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6583
p.P2161H	DU-145	prostate	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6583
p.R2157Q	SIDM01002	Breast Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6218
p.R2157Q	SIDM00265	Ewing's Sarcoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6218
p.R2157Q	SIDM00847	Rhabdomyosarcoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6218
p.Y2172C	SIDM00846	Cervical Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.0833
p.L2170F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1389
p.L2170F	ACH-000904	Lung Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.1389
p.L2170F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1389
p.L2169I	SIDM01609	Endometrial Carcinoma	GDSC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.L2152M	ACH-000707	Lymphoma	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.25
p.L2152M	ACH-002252	Lymphoma	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.25
p.L2152M	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.25
p.N2169S	ACH-001568	Skin Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.N2169S	ACH-002159	Skin Cancer	CCLE	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.N2169S	M14	skin	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.L2169F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1667
p.N2150S	M14	skin	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1944
p.S2146R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.0833
p.E2147K	DBTRG-05MG	central_nervous_system	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111
p.R2156W	HCC2998	large_intestine	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.8634
p.L2151F	NCI-H1770	lung	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.2222
p.S2170R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1389
p.P2160H	DU-145	prostate	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.6583
p.E2171K	DBTRG-05MG	central_nervous_system	COSMIC	SRRQLPPVP	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRQLPPVP

Degron related mutations and impact score

Drug responses associated with CACNA1E mutations

All proteins holding degron of SRRQLPPVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15878	Voltage-dependent R-type calcium channel subunit alpha-1E	DEG_APCC_DBOX_1	2155:2163	SRRQLPPVP	APC,CDC20,FZR1	0.9659	More...