DegronMD - Q16288(NTRK3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E412K	TCGA-06-5416	GBM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.E412K	TCGA-AA-A010	COAD	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.E412K	TCGA-E6-A1M0	UCEC	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.E412K	DO10880	GBM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.E412K	DO43682	UCEC	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.H423N	TCGA-CV-7178	HNSC	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.25
p.H423N	TCGA-EE-A3AG	SKCM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.25
p.H423N	DO14774	HNSC	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.25
p.H423N	DO37471	SKCM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.25
p.T404M	TCGA-F5-6814	READ	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0833
p.T404M	DO36556	READ	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0833
p.T404M	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0833
p.T404M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0833
p.P417L	TCGA-W3-A825	SKCM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.7582
p.P417L	DO51272	SKCM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.7582
p.P417H	DO229018	LICA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.7694
p.F407I	DO50893	LICA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.1667
p.P417R	DO222662	MELA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.7512
p.I408N	DO46844	RECA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.1944
p.E412G	SIDM00350	Head and Neck Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.E412G	SAT	upper aerodigestive tract	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.3056
p.D411N	SIDM00653	Small Cell Lung Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.2778
p.D411N	NCI-H1092	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.2778
p.T416A	SIDM01611	Endometrial Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.7139
p.R420H	ACH-000461	Bile Duct Cancer	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.8244
p.P418S	ACH-000588	Myeloma	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation altering degron motif	0.5641
p.N424K	ACH-000924	Lung Cancer	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation substituting flanking lysine	0.3333
p.N424K	NCI-H2172	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation substituting flanking lysine	0.3333
p.E404G	SAT	upper aerodigestive tract	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0833
p.D403N	NCI-H1092	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	413:420	Mutation rewiring degron network	0.0556

Kaplan plot for NTRK3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NTRK3

UniProt ID: Q16288

Entrez ID: 4916

Protein name: NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NTRK3 in