DegronMD

Uniprot ID: Q16288

Source protein: NT-3 growth factor receptor

Source gene: NTRK3

Class: DEG_SCF_FBW7_1

Location: 413:420

E3 ligase: FBXW7

DEGRON score: 0.8016

ASA_SCORE: 69.05

COIL: 0.8573

CONS_SCORE: 0.3879

DSS_SCORE: 0.4357

HELIX: 0.0196

FCONS_SCORE: 1.161

RIG_SCORE: 0.7357

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E412K	TCGA-06-5416	GBM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.E412K	TCGA-AA-A010	COAD	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.E412K	TCGA-E6-A1M0	UCEC	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.E412K	DO10880	GBM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.E412K	DO43682	UCEC	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.H423N	TCGA-CV-7178	HNSC	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.25
p.H423N	TCGA-EE-A3AG	SKCM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.25
p.H423N	DO14774	HNSC	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.25
p.H423N	DO37471	SKCM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.25
p.T404M	TCGA-F5-6814	READ	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.0833
p.T404M	DO36556	READ	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.0833
p.T404M	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	0.0833
p.T404M	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.0833
p.P417L	TCGA-W3-A825	SKCM	TCGA	VSPTPPIT	DEG_SCF_FBW7_1	0.7582
p.P417L	DO51272	SKCM	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.7582
p.P417H	DO229018	LICA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.7694
p.F407I	DO50893	LICA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.1667
p.P417R	DO222662	MELA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.7512
p.I408N	DO46844	RECA	ICGC	VSPTPPIT	DEG_SCF_FBW7_1	0.1944
p.E412G	SIDM00350	Head and Neck Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.E412G	SAT	upper_aerodigestive_tract	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.3056
p.D411N	SIDM00653	Small Cell Lung Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	0.2778
p.D411N	NCI-H1092	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.2778
p.T416A	SIDM01611	Endometrial Carcinoma	GDSC	VSPTPPIT	DEG_SCF_FBW7_1	0.7139
p.R420H	ACH-000461	Bile Duct Cancer	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	0.8244
p.P418S	ACH-000588	Myeloma	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	0.5641
p.N424K	ACH-000924	Lung Cancer	CCLE	VSPTPPIT	DEG_SCF_FBW7_1	0.3333
p.N424K	NCI-H2172	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.3333
p.E404G	SAT	upper_aerodigestive_tract	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.0833
p.D403N	NCI-H1092	lung	COSMIC	VSPTPPIT	DEG_SCF_FBW7_1	0.0556

Drug responses associated with NTRK3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.N522K (No)	GDSC	Lestaurtinib	12.3
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.N522K (No)	GDSC	AZD1332	6.0468
SIDM00554	UNCLASSIFIED\|ovary	p.V21F (No)	GDSC	Lestaurtinib	2.1171
SIDM00554	UNCLASSIFIED\|ovary	p.V21F (No)	GDSC	AZD1332	4.6351
SIDM00554	UNCLASSIFIED\|ovary	p.V21F (No)	GDSC	AZD1332	288.22
SIDM00720	MESO\|mesothelioma	p.V451I (No)	GDSC	Lestaurtinib	0.5831
SIDM00720	MESO\|mesothelioma	p.V451I (No)	GDSC	AZD1332	2.1285
SIDM00720	MESO\|mesothelioma	p.V451I (No)	GDSC	AZD1332	28.812
SIDM01164	LGG\|glioma	p.R306C (No)	GDSC	Lestaurtinib	1.2119
SIDM01164	LGG\|glioma	p.R306C (No)	GDSC	AZD1332	4.992
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S165N (No)	GDSC	Lestaurtinib	0.9313
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S165N (No)	GDSC	AZD1332	4.9229
SIDM00498	COREAD\|large_intestine	p.L56fs*30 (No)	GDSC	Lestaurtinib	0.1512
SIDM00498	COREAD\|large_intestine	p.L56fs*30 (No)	GDSC	AZD1332	9.5088
SIDM00498	COREAD\|large_intestine	p.L56fs*30 (No)	GDSC	AZD1332	73.845
SIDM01029	ESCA\|oesophagus	p.H610Y (No)	GDSC	Lestaurtinib	0.3719
SIDM01029	ESCA\|oesophagus	p.H610Y (No)	GDSC	AZD1332	3.8037
SIDM01029	ESCA\|oesophagus	p.H610Y (No)	GDSC	AZD1332	12.633
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.P634T (No)	GDSC	Lestaurtinib	1.3832
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.P634T (No)	GDSC	AZD1332	36.8623
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.P634T (No)	GDSC	AZD1332	356.93
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V468M (No)	GDSC	Lestaurtinib	0.1181
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V468M (No)	GDSC	AZD1332	6.9145
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V468M (No)	GDSC	AZD1332	14.447
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T404M (Yes)	GDSC	Lestaurtinib	0.1181
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T404M (Yes)	GDSC	AZD1332	6.9145
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T404M (Yes)	GDSC	AZD1332	14.447
SIDM00798	UNCLASSIFIED\|rhabdomyosarcoma	p.N714S (No)	GDSC	Lestaurtinib	0.0759
SIDM00798	UNCLASSIFIED\|rhabdomyosarcoma	p.N714S (No)	GDSC	AZD1332	1.5483
SIDM00798	UNCLASSIFIED\|rhabdomyosarcoma	p.N714S (No)	GDSC	AZD1332	37.16
SIDM00350	HNSC\|head_and_neck	p.E412G (Yes)	GDSC	Lestaurtinib	0.5305
SIDM00350	HNSC\|head_and_neck	p.E412G (Yes)	GDSC	AZD1332	5.1011
SIDM00350	HNSC\|head_and_neck	p.E412G (Yes)	GDSC	AZD1332	70.087
SIDM00045	STAD\|stomach	p.L115P (No)	GDSC	Lestaurtinib	0.0546
SIDM00045	STAD\|stomach	p.L115P (No)	GDSC	AZD1332	0.105
SIDM00250	ESCA\|oesophagus	p.T749R (No)	GDSC	Lestaurtinib	0.2867
SIDM00250	ESCA\|oesophagus	p.T749R (No)	GDSC	AZD1332	14.7752
SIDM00250	ESCA\|oesophagus	p.T749R (No)	GDSC	AZD1332	240.15
SIDM00250	ESCA\|oesophagus	p.V21F (No)	GDSC	Lestaurtinib	0.2867
SIDM00250	ESCA\|oesophagus	p.V21F (No)	GDSC	AZD1332	14.7752
SIDM00250	ESCA\|oesophagus	p.V21F (No)	GDSC	AZD1332	240.15
SIDM00527	COREAD\|large_intestine	p.G595D (No)	GDSC	Lestaurtinib	0.135
SIDM00527	COREAD\|large_intestine	p.G595D (No)	GDSC	AZD1332	6.9483
SIDM00527	COREAD\|large_intestine	p.G595D (No)	GDSC	AZD1332	197.41
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.V21F (No)	GDSC	Lestaurtinib	0.6611
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.V21F (No)	GDSC	AZD1332	4.4088
SIDM00199	UNCLASSIFIED\|bone_other	p.R809M (No)	GDSC	Lestaurtinib	0.4758
SIDM00199	UNCLASSIFIED\|bone_other	p.R809M (No)	GDSC	AZD1332	10.6067
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y352C (No)	GDSC	Lestaurtinib	0.0695
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y352C (No)	GDSC	AZD1332	16.6738
SIDM01007	ALL\|lymphoblastic_leukemia	p.Y352C (No)	GDSC	AZD1332	28.554
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.A555G (No)	GDSC	Lestaurtinib	25.0396
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.A555G (No)	GDSC	AZD1332	4.3298
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.A555G (No)	GDSC	AZD1332	93.66
SIDM00943	PAAD\|pancreas	p.T490M (No)	GDSC	Lestaurtinib	3.1842
SIDM00943	PAAD\|pancreas	p.T490M (No)	GDSC	AZD1332	10.837
SIDM00251	STAD\|stomach	p.G587R (No)	GDSC	Lestaurtinib	1.0248
SIDM00251	STAD\|stomach	p.G587R (No)	GDSC	AZD1332	28.4398
SIDM00251	STAD\|stomach	p.G587R (No)	GDSC	AZD1332	315.65
SIDM01099	NB\|neuroblastoma	p.D499N (No)	GDSC	Lestaurtinib	0.5763
SIDM01099	NB\|neuroblastoma	p.D499N (No)	GDSC	AZD1332	7.5829
SIDM01090	COREAD\|large_intestine	p.L481V (No)	GDSC	Lestaurtinib	0.2873
SIDM01090	COREAD\|large_intestine	p.L481V (No)	GDSC	AZD1332	6.455
SIDM01090	COREAD\|large_intestine	p.L481V (No)	GDSC	AZD1332	174.7
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.K797E (No)	GDSC	Lestaurtinib	2.6646
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.K797E (No)	GDSC	AZD1332	8.4188
SIDM01259	ALL\|lymphoblastic_leukemia	p.L182fs*12 (No)	GDSC	Lestaurtinib	0.2633
SIDM01259	ALL\|lymphoblastic_leukemia	p.L182fs*12 (No)	GDSC	AZD1332	9.2278
SIDM01259	ALL\|lymphoblastic_leukemia	p.L182fs*12 (No)	GDSC	AZD1332	295.56
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.P55R (No)	GDSC	Lestaurtinib	3.4287
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.P55R (No)	GDSC	AZD1332	4.3668
SIDM00751	LUAD\|lung_NSCLC_adenocarcinoma	p.P55R (No)	GDSC	AZD1332	57.983
SIDM01025	ESCA\|oesophagus	p.V21F (No)	GDSC	Lestaurtinib	1.9805
SIDM01025	ESCA\|oesophagus	p.V21F (No)	GDSC	AZD1332	11.9659
SIDM01025	ESCA\|oesophagus	p.V21F (No)	GDSC	AZD1332	15.651
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.R306H (No)	GDSC	Lestaurtinib	3.7739
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.R306H (No)	GDSC	AZD1332	18.8029
SIDM00568	STAD\|stomach	p.V21F (No)	GDSC	Lestaurtinib	0.1813
SIDM00568	STAD\|stomach	p.V21F (No)	GDSC	AZD1332	26.5064
SIDM00568	STAD\|stomach	p.V21F (No)	GDSC	AZD1332	290.9
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.T274M (No)	GDSC	Lestaurtinib	0.7169
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.T274M (No)	GDSC	AZD1332	7.1499
SIDM00217	COREAD\|large_intestine	p.T748I (No)	GDSC	AZD1332	152.1628
SIDM00217	COREAD\|large_intestine	p.T748I (No)	GDSC	AZD1332	171.37
SIDM00217	COREAD\|large_intestine	p.R645H (No)	GDSC	AZD1332	152.1628
SIDM00217	COREAD\|large_intestine	p.R645H (No)	GDSC	AZD1332	171.37
SIDM00217	COREAD\|large_intestine	p.W144* (No)	GDSC	AZD1332	152.1628
SIDM00217	COREAD\|large_intestine	p.W144* (No)	GDSC	AZD1332	171.37
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.H729N (No)	GDSC	Lestaurtinib	0.2202
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.H729N (No)	GDSC	AZD1332	2.6903
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.H729N (No)	GDSC	AZD1332	17.456
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P498H (No)	GDSC	Lestaurtinib	0.2202
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P498H (No)	GDSC	AZD1332	2.6903
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P498H (No)	GDSC	AZD1332	17.456
SIDM00933	BRCA\|breast	p.V451I (No)	GDSC	Lestaurtinib	0.2537
SIDM00933	BRCA\|breast	p.V451I (No)	GDSC	AZD1332	3.5458
SIDM00933	BRCA\|breast	p.V451I (No)	GDSC	AZD1332	15.392
SIDM00216	COREAD\|large_intestine	p.R343Q (No)	GDSC	AZD1332	26.186
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V799L (No)	GDSC	Lestaurtinib	3.5855
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V799L (No)	GDSC	AZD1332	3.3433
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V799L (No)	GDSC	AZD1332	308.51
SIDM00282	COREAD\|large_intestine	p.N690I (No)	GDSC	Lestaurtinib	37.5249
SIDM00282	COREAD\|large_intestine	p.N690I (No)	GDSC	AZD1332	26.1203
SIDM00282	COREAD\|large_intestine	p.N690I (No)	GDSC	AZD1332	236.66
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.S275N (No)	GDSC	Lestaurtinib	2.623
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.S275N (No)	GDSC	AZD1332	18.0447
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.S275N (No)	GDSC	AZD1332	43.063
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.S775T (No)	GDSC	Lestaurtinib	0.4161
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.S775T (No)	GDSC	AZD1332	3.2614
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.S775T (No)	GDSC	AZD1332	225.92
SIDM00660	COREAD\|large_intestine	p.T707M (No)	GDSC	Lestaurtinib	0.3509
SIDM00660	COREAD\|large_intestine	p.T707M (No)	GDSC	AZD1332	4.1424
SIDM00660	COREAD\|large_intestine	p.T707M (No)	GDSC	AZD1332	96.184
SIDM00660	COREAD\|large_intestine	p.C36Y (No)	GDSC	Lestaurtinib	0.3509
SIDM00660	COREAD\|large_intestine	p.C36Y (No)	GDSC	AZD1332	4.1424
SIDM00660	COREAD\|large_intestine	p.C36Y (No)	GDSC	AZD1332	96.184
SIDM01137	PAAD\|pancreas	p.F200S (No)	GDSC	Lestaurtinib	7.5562
SIDM01137	PAAD\|pancreas	p.F200S (No)	GDSC	AZD1332	4.1162
SIDM00636	MM\|haematopoietic_neoplasm_other	p.T230P (No)	GDSC	Lestaurtinib	0.1247
SIDM00636	MM\|haematopoietic_neoplasm_other	p.T230P (No)	GDSC	AZD1332	12.6142
SIDM00636	MM\|haematopoietic_neoplasm_other	p.T230P (No)	GDSC	AZD1332	82.456
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.V704D (No)	GDSC	Lestaurtinib	0.4525
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.V704D (No)	GDSC	AZD1332	1.8186
SIDM00730	SCLC\|lung_small_cell_carcinoma	p.V704D (No)	GDSC	AZD1332	210.48
SIDM01147	STAD\|stomach	p.E211V (No)	GDSC	Lestaurtinib	4.8402
SIDM01147	STAD\|stomach	p.E211V (No)	GDSC	AZD1332	25.8667
SIDM01147	STAD\|stomach	p.E211V (No)	GDSC	AZD1332	203.26
SIDM00783	COREAD\|large_intestine	p.I837T (No)	GDSC	Lestaurtinib	0.1361
SIDM00783	COREAD\|large_intestine	p.I837T (No)	GDSC	AZD1332	2.2809
SIDM00783	COREAD\|large_intestine	p.I837T (No)	GDSC	AZD1332	16.108
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.T563N (No)	GDSC	Lestaurtinib	0.707
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.T563N (No)	GDSC	AZD1332	2.2462
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.Y555C (No)	GDSC	Lestaurtinib	0.707
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.Y555C (No)	GDSC	AZD1332	2.2462
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y353* (No)	GDSC	Lestaurtinib	0.5359
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y353* (No)	GDSC	AZD1332	8.3204
SIDM00379	GBM\|glioma	p.R645C (No)	GDSC	Lestaurtinib	0.4379
SIDM00379	GBM\|glioma	p.R645C (No)	GDSC	AZD1332	7.0057
SIDM00379	GBM\|glioma	p.R645C (No)	GDSC	AZD1332	311.12
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P586S (No)	GDSC	Lestaurtinib	0.4145
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P586S (No)	GDSC	AZD1332	5.8085
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.P586S (No)	GDSC	AZD1332	15.32
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E566D (No)	GDSC	Lestaurtinib	0.4145
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E566D (No)	GDSC	AZD1332	5.8085
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E566D (No)	GDSC	AZD1332	15.32
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.A573S (No)	GDSC	Lestaurtinib	0.6252
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.E223D (No)	GDSC	Lestaurtinib	0.2983
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.E223D (No)	GDSC	AZD1332	5.967
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.E223D (No)	GDSC	AZD1332	292.69
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.S215G (No)	GDSC	Lestaurtinib	36.9588
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.S215G (No)	GDSC	AZD1332	35.4553
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.S215G (No)	GDSC	AZD1332	162.48
SIDM00975	SKCM\|melanoma	p.D584N (No)	GDSC	Lestaurtinib	0.2094
SIDM00975	SKCM\|melanoma	p.D584N (No)	GDSC	AZD1332	9.8871
SIDM00975	SKCM\|melanoma	p.D584N (No)	GDSC	AZD1332	436.51
SIDM00789	COREAD\|large_intestine	p.D535N (No)	GDSC	Lestaurtinib	0.1456
SIDM00789	COREAD\|large_intestine	p.D535N (No)	GDSC	AZD1332	10.3643
SIDM00789	COREAD\|large_intestine	p.D535N (No)	GDSC	AZD1332	12.931
SIDM00534	COREAD\|large_intestine	p.D624Y (No)	GDSC	Lestaurtinib	1.2424
SIDM00534	COREAD\|large_intestine	p.D624Y (No)	GDSC	AZD1332	7.9228
SIDM00534	COREAD\|large_intestine	p.D624Y (No)	GDSC	AZD1332	52.928
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K746R (No)	GDSC	Lestaurtinib	1.3681
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K746R (No)	GDSC	AZD1332	5.1286
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.K746R (No)	GDSC	AZD1332	95.856
SIDM00487	COREAD\|large_intestine	p.Y604C (No)	GDSC	Lestaurtinib	2.9211
SIDM00487	COREAD\|large_intestine	p.Y604C (No)	GDSC	AZD1332	26.9247
SIDM00487	COREAD\|large_intestine	p.Y604C (No)	GDSC	AZD1332	29.735
SIDM00582	PAAD\|pancreas	p.Q249L (No)	GDSC	Lestaurtinib	0.8861
SIDM00582	PAAD\|pancreas	p.Q249L (No)	GDSC	AZD1332	4.295
SIDM00582	PAAD\|pancreas	p.Q249L (No)	GDSC	AZD1332	68.303
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q172H (No)	GDSC	Lestaurtinib	0.6164
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q172H (No)	GDSC	AZD1332	7.3799
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q172H (No)	GDSC	AZD1332	50.049
SIDM00255	NB\|neuroblastoma	p.S296I (No)	GDSC	Lestaurtinib	0.4949
SIDM00255	NB\|neuroblastoma	p.S296I (No)	GDSC	AZD1332	7.969
SIDM00120	PRAD\|prostate	p.G608C (No)	GDSC	Lestaurtinib	1.5774
SIDM00120	PRAD\|prostate	p.G608C (No)	GDSC	AZD1332	9.973
SIDM00120	PRAD\|prostate	p.G608C (No)	GDSC	AZD1332	499.93
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.H677Y (No)	GDSC	Lestaurtinib	2.4274
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.H677Y (No)	GDSC	AZD1332	8.2927
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.H677Y (No)	GDSC	AZD1332	121.15
SIDM00541	COREAD\|large_intestine	p.I83L (No)	GDSC	Lestaurtinib	2.5935
SIDM00541	COREAD\|large_intestine	p.I83L (No)	GDSC	AZD1332	12.318
SIDM00541	COREAD\|large_intestine	p.I83L (No)	GDSC	AZD1332	50.187
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R645C (No)	GDSC	Lestaurtinib	0.697
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R645C (No)	GDSC	AZD1332	16.949
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R645C (No)	GDSC	AZD1332	22.733
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.G393D (No)	GDSC	Lestaurtinib	0.846
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.G393D (No)	GDSC	AZD1332	38.7505
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.G393D (No)	GDSC	AZD1332	109.95
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R702T (No)	GDSC	Lestaurtinib	0.4766
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R702T (No)	GDSC	AZD1332	53.333
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R702T (No)	GDSC	AZD1332	21.601
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M567T (No)	GDSC	Lestaurtinib	0.4766
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M567T (No)	GDSC	AZD1332	53.333
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M567T (No)	GDSC	AZD1332	21.601
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.V598I (No)	GDSC	Lestaurtinib	2.5578
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.V598I (No)	GDSC	AZD1332	19.9579
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.V598I (No)	GDSC	AZD1332	74.456
SIDM01240	SKCM\|melanoma	p.G608D (No)	GDSC	Lestaurtinib	0.1756
SIDM01240	SKCM\|melanoma	p.G608D (No)	GDSC	AZD1332	33.4452
SIDM00491	THCA\|thyroid	p.V21F (No)	GDSC	Lestaurtinib	0.414
SIDM00491	THCA\|thyroid	p.V21F (No)	GDSC	AZD1332	6.7293
SIDM00491	THCA\|thyroid	p.V21F (No)	GDSC	AZD1332	24.372
SIDM00120	PRAD\|prostate	p.N262fs*7 (No)	GDSC	Lestaurtinib	1.5774
SIDM00120	PRAD\|prostate	p.N262fs*7 (No)	GDSC	AZD1332	9.973
SIDM00120	PRAD\|prostate	p.N262fs*7 (No)	GDSC	AZD1332	499.93
SIDM00537	COREAD\|large_intestine	p.I783N (No)	GDSC	Lestaurtinib	0.1502
SIDM00537	COREAD\|large_intestine	p.I783N (No)	GDSC	AZD1332	5.4949
SIDM00537	COREAD\|large_intestine	p.I783N (No)	GDSC	AZD1332	6.4177
SIDM00537	COREAD\|large_intestine	p.I321T (No)	GDSC	Lestaurtinib	0.1502
SIDM00537	COREAD\|large_intestine	p.I321T (No)	GDSC	AZD1332	5.4949
SIDM00537	COREAD\|large_intestine	p.I321T (No)	GDSC	AZD1332	6.4177
SIDM00148	BRCA\|breast	p.G137V (No)	GDSC	Lestaurtinib	1.1644
SIDM00148	BRCA\|breast	p.G137V (No)	GDSC	AZD1332	5.6093
SIDM00148	BRCA\|breast	p.G137V (No)	GDSC	AZD1332	76.087
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D411N (Yes)	GDSC	Lestaurtinib	4.5585
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D411N (Yes)	GDSC	AZD1332	56.5103
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D411N (Yes)	GDSC	AZD1332	219.91
SIDM00238	OV\|ovary	p.A8V (No)	GDSC	Lestaurtinib	0.9004
SIDM00238	OV\|ovary	p.A8V (No)	GDSC	AZD1332	4.8217
SIDM00238	OV\|ovary	p.A8V (No)	GDSC	AZD1332	287
SIDM00416	DLBC\|B_cell_lymphoma	p.V21F (No)	GDSC	Lestaurtinib	0.1702
SIDM00416	DLBC\|B_cell_lymphoma	p.V21F (No)	GDSC	AZD1332	15.6554
SIDM00416	DLBC\|B_cell_lymphoma	p.V21F (No)	GDSC	AZD1332	18.542
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.V307L (No)	GDSC	Lestaurtinib	1.2184
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.V307L (No)	GDSC	AZD1332	15.3688
SIDM00332	BRCA\|breast	p.H254Y (No)	GDSC	Lestaurtinib	0.4824
SIDM00332	BRCA\|breast	p.H254Y (No)	GDSC	AZD1332	0.2106
SIDM00332	BRCA\|breast	p.H254Y (No)	GDSC	AZD1332	1.4966
SIDM00193	COREAD\|large_intestine	p.R711M (No)	GDSC	Lestaurtinib	1.9368
SIDM00193	COREAD\|large_intestine	p.R711M (No)	GDSC	AZD1332	8.82
SIDM00193	COREAD\|large_intestine	p.R711M (No)	GDSC	AZD1332	125.9
SIDM00193	COREAD\|large_intestine	p.E577* (No)	GDSC	Lestaurtinib	1.9368
SIDM00193	COREAD\|large_intestine	p.E577* (No)	GDSC	AZD1332	8.82
SIDM00193	COREAD\|large_intestine	p.E577* (No)	GDSC	AZD1332	125.9
SIDM00193	COREAD\|large_intestine	p.R89H (No)	GDSC	Lestaurtinib	1.9368
SIDM00193	COREAD\|large_intestine	p.R89H (No)	GDSC	AZD1332	8.82
SIDM00193	COREAD\|large_intestine	p.R89H (No)	GDSC	AZD1332	125.9
SIDM00086	KIRC\|kidney	p.V308L (No)	GDSC	Lestaurtinib	0.7691
SIDM00086	KIRC\|kidney	p.V308L (No)	GDSC	AZD1332	1.9073
SIDM00086	KIRC\|kidney	p.V308L (No)	GDSC	AZD1332	3.29

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSPTPPIT

Degron related mutations and impact score

Drug responses associated with NTRK3 mutations

All proteins holding degron of VSPTPPIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16288	NT-3 growth factor receptor	DEG_SCF_FBW7_1	413:420	VSPTPPIT	FBXW7	0.8016	More...