DegronMD - Q16342(PDCD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q99H	TCGA-39-5024	LUSC	TCGA	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1944
p.Q99H	DO27240	LUSC	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1944
p.E114D	TCGA-AP-A1E0	UCEC	TCGA	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.E114D	DO43154	UCEC	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.P111Q	TCGA-AX-A1CE	UCEC	TCGA	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.7035
p.P111Q	DO42280	UCEC	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.7035
p.E119K	TCGA-D3-A3MR	SKCM	TCGA	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1111
p.E119K	DO47256	SKCM	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1111
p.P118Q	TCGA-FS-A1ZB	SKCM	TCGA	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1389
p.P118Q	DO37886	SKCM	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1389
p.R102G	DO229257	THCA	ICGC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.2778
p.Y109C	SIDM00276	Biliary Tract Carcinoma	GDSC	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.5976
p.Y109C	ACH-001858	Bile Duct Cancer	CCLE	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.5976
p.Y109C	ACH-002237	Bile Duct Cancer	CCLE	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.5976
p.Y109C	ETK-1	biliary tract	COSMIC	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.5976
p.E110K	ACH-000279	Bone Cancer	CCLE	NDFYSYEP	CBL_PTK	104:111	Mutation altering degron motif	0.591
p.A119T	HCC2998	large intestine	COSMIC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1111
p.S97C	TE-9	oesophagus	COSMIC	NDFYSYEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1389

Kaplan plot for PDCD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDCD2

UniProt ID: Q16342

Entrez ID: 5134

Protein name: Programmed cell death protein 2 (Zinc finger MYND domain-containing protein 7) (Zinc finger protein Rp-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDCD2 in