DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NDFYSYEP
Uniprot ID:
Q16342
Source protein:
Programmed cell death protein 2
Source gene:
PDCD2
Class:
CBL_PTK
Location:
104:111
E3 ligase:
CBL
DEGRON score:
0.7588
ASA_SCORE:
86.1625
COIL:
0.8444
CONS_SCORE:
0.5433
DSS_SCORE:
0.5278
HELIX:
0.0763
FCONS_SCORE:
1.1292
RIG_SCORE:
0.7074
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q99H
TCGA-39-5024
LUSC
TCGA
NDFYSYEP
CBL_PTK
0.1944
p.Q99H
DO27240
LUSC
ICGC
NDFYSYEP
CBL_PTK
0.1944
p.E114D
TCGA-AP-A1E0
UCEC
TCGA
NDFYSYEP
CBL_PTK
0.25
p.E114D
DO43154
UCEC
ICGC
NDFYSYEP
CBL_PTK
0.25
p.P111Q
TCGA-AX-A1CE
UCEC
TCGA
NDFYSYEP
CBL_PTK
0.7035
p.P111Q
DO42280
UCEC
ICGC
NDFYSYEP
CBL_PTK
0.7035
p.E119K
TCGA-D3-A3MR
SKCM
TCGA
NDFYSYEP
CBL_PTK
0.1111
p.E119K
DO47256
SKCM
ICGC
NDFYSYEP
CBL_PTK
0.1111
p.P118Q
TCGA-FS-A1ZB
SKCM
TCGA
NDFYSYEP
CBL_PTK
0.1389
p.P118Q
DO37886
SKCM
ICGC
NDFYSYEP
CBL_PTK
0.1389
p.R102G
DO229257
THCA
ICGC
NDFYSYEP
CBL_PTK
0.2778
p.Y109C
SIDM00276
Biliary Tract Carcinoma
GDSC
NDFYSYEP
CBL_PTK
0.5976
p.Y109C
ACH-001858
Bile Duct Cancer
CCLE
NDFYSYEP
CBL_PTK
0.5976
p.Y109C
ACH-002237
Bile Duct Cancer
CCLE
NDFYSYEP
CBL_PTK
0.5976
p.Y109C
ETK-1
biliary_tract
COSMIC
NDFYSYEP
CBL_PTK
0.5976
p.E110K
ACH-000279
Bone Cancer
CCLE
NDFYSYEP
CBL_PTK
0.591
p.A119T
HCC2998
large_intestine
COSMIC
NDFYSYEP
CBL_PTK
0.1111
p.S97C
TE-9
oesophagus
COSMIC
NDFYSYEP
CBL_PTK
0.1389
Drug responses associated with PDCD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NDFYSYEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16342
Programmed cell death protein 2
CBL_PTK
104:111
NDFYSYEP
CBL
0.7588
More...
