DegronMD - Q16515(ASIC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L410I	TCGA-AX-A05Z	UCEC	TCGA	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation altering degron motif	0.7174
p.L410I	DO40884	UCEC	ICGC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation altering degron motif	0.7174
p.L410F	TCGA-D3-A5GO	SKCM	TCGA	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation altering degron motif	0.6981
p.L412R	DO7801	COAD	ICGC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.2778
p.G399C	DO231778	LINC	ICGC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.1667
p.D405E	DO45293	LIRI	ICGC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation altering degron motif	0.6758
p.R419C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.0833
p.R419C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.0833
p.T418A	SIDM01175	Other Sarcomas	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.1111
p.T418A	SW684	soft tissue	COSMIC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.1111
p.A402T	SIDM00318	Kidney Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.25
p.A402T	VMRC-RCW	kidney	COSMIC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.25
p.K404R	SIDM00172	Head and Neck Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.3056
p.K404R	BB30-HNC	upper aerodigestive tract	COSMIC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.3056
p.P414A	SIDM00884	Breast Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.2222
p.P414A	HCC1395	breast	COSMIC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.2222
p.E395A	SIDM01770	Gastric Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation rewiring degron network	0.0556
p.L405R	ACH-000025	Brain Cancer	CCLE	LDIFFE	LIG_APCC_ABBA_1	405:410	Mutation altering degron motif	0.8428

Kaplan plot for ASIC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASIC2

UniProt ID: Q16515

Entrez ID: 40

Protein name: Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASIC2 in