DegronMD

Uniprot ID: Q16515

Source protein: Acid-sensing ion channel 2

Source gene: ASIC2

Class: LIG_APCC_ABBA_1

Location: 405:410

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5132

ASA_SCORE: 40.15

COIL: 0.1435

CONS_SCORE: 0.6031

DSS_SCORE: 0.0114

HELIX: 0.0295

FCONS_SCORE: 1.2472

RIG_SCORE: 1.0279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L410I	TCGA-AX-A05Z	UCEC	TCGA	LDIFFE	LIG_APCC_ABBA_1	0.7174
p.L410I	DO40884	UCEC	ICGC	LDIFFE	LIG_APCC_ABBA_1	0.7174
p.L410F	TCGA-D3-A5GO	SKCM	TCGA	LDIFFE	LIG_APCC_ABBA_1	0.6981
p.L412R	DO7801	COAD	ICGC	LDIFFE	LIG_APCC_ABBA_1	0.2778
p.G399C	DO231778	LINC	ICGC	LDIFFE	LIG_APCC_ABBA_1	0.1667
p.D405E	DO45293	LIRI	ICGC	LDIFFE	LIG_APCC_ABBA_1	0.6758
p.R419C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.0833
p.R419C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LDIFFE	LIG_APCC_ABBA_1	0.0833
p.T418A	SIDM01175	Other Sarcomas	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.1111
p.T418A	SW684	soft_tissue	COSMIC	LDIFFE	LIG_APCC_ABBA_1	0.1111
p.A402T	SIDM00318	Kidney Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.25
p.A402T	VMRC-RCW	kidney	COSMIC	LDIFFE	LIG_APCC_ABBA_1	0.25
p.K404R	SIDM00172	Head and Neck Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.3056
p.K404R	BB30-HNC	upper_aerodigestive_tract	COSMIC	LDIFFE	LIG_APCC_ABBA_1	0.3056
p.P414A	SIDM00884	Breast Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.2222
p.P414A	HCC1395	breast	COSMIC	LDIFFE	LIG_APCC_ABBA_1	0.2222
p.E395A	SIDM01770	Gastric Carcinoma	GDSC	LDIFFE	LIG_APCC_ABBA_1	0.0556
p.L405R	ACH-000025	Brain Cancer	CCLE	LDIFFE	LIG_APCC_ABBA_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16515	Acid-sensing ion channel 2	LIG_APCC_ABBA_1	405:410	LDIFFE	APC,CDC20,FZR1	0.5132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons