DegronMD - Q16555(DPYSL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V506A	TCGA-19-4065	GBM	TCGA	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1389
p.V513I	TCGA-AU-6004	COAD	TCGA	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation altering degron motif	0.5965
p.P515S	TCGA-EB-A5UL	SKCM	TCGA	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation altering degron motif	0.6752
p.T521M	TCGA-EC-A24G	UCEC	TCGA	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking phosphorylation signal	0.6944
p.T509M	TCGA-G4-6586	COAD	TCGA	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking phosphorylation signal	0.6667
p.I510T	DO12712	GBM	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.25
p.A508S	DO229018	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1944
p.V523L	DO229041	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1944
p.N513S	DO50867	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation altering degron motif	0.7069
p.P515L	DO229446	SKCA	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation altering degron motif	0.7582
p.P525S	DO219481	SKCM	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking ubiquitination signal	0.5833
p.Q509H	DO41020	UCEC	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking phosphorylation signal	0.6667
p.R517H	DO43891	UCEC	ICGC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation altering degron motif	0.8244
p.I506V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1389
p.I506V	EMC-BAC-2	lung	COSMIC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1389
p.S526F	SIDM00217	Colorectal Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1111
p.S526F	SNU-1040	large intestine	COSMIC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1111
p.D520N	SIDM01609	Endometrial Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking ubiquitination signal	0.7222
p.A524V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation rewiring degron network	0.1667
p.G507D	HCT-15	large intestine	COSMIC	VTPASS	DEG_SCF_FBW7_1	513:518	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for DPYSL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPYSL2

UniProt ID: Q16555

Entrez ID: 1808

Protein name: Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPYSL2 in