DegronMD

Uniprot ID: Q16555

Source protein: Dihydropyrimidinase-related protein 2

Source gene: DPYSL2

Class: DEG_SCF_FBW7_1

Location: 513:518

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 75.6667

COIL: 0.8598

CONS_SCORE: 0.2296

DSS_SCORE: 0.5558

HELIX: 0.1125

FCONS_SCORE: 1.0219

RIG_SCORE: 0.6877

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R517H	DO43891	UCEC	ICGC	VTPASS	DEG_SCF_FBW7_1	0.8244
p.P515L	DO229446	SKCA	ICGC	VTPASS	DEG_SCF_FBW7_1	0.7582
p.D520N	SIDM01609	Endometrial Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	0.7222
p.N513S	DO50867	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	0.7069
p.T521M	TCGA-EC-A24G	UCEC	TCGA	VTPASS	DEG_SCF_FBW7_1	0.6944
p.P515S	TCGA-EB-A5UL	SKCM	TCGA	VTPASS	DEG_SCF_FBW7_1	0.6752
p.T509M	TCGA-G4-6586	COAD	TCGA	VTPASS	DEG_SCF_FBW7_1	0.6667
p.Q509H	DO41020	UCEC	ICGC	VTPASS	DEG_SCF_FBW7_1	0.6667
p.G507D	HCT-15	large_intestine	COSMIC	VTPASS	DEG_SCF_FBW7_1	0.6111
p.V513I	TCGA-AU-6004	COAD	TCGA	VTPASS	DEG_SCF_FBW7_1	0.5965
p.P525S	DO219481	SKCM	ICGC	VTPASS	DEG_SCF_FBW7_1	0.5833
p.I510T	DO12712	GBM	ICGC	VTPASS	DEG_SCF_FBW7_1	0.25
p.A508S	DO229018	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	0.1944
p.V523L	DO229041	LICA	ICGC	VTPASS	DEG_SCF_FBW7_1	0.1944
p.A524V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPASS	DEG_SCF_FBW7_1	0.1667
p.V506A	TCGA-19-4065	GBM	TCGA	VTPASS	DEG_SCF_FBW7_1	0.1389
p.I506V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	0.1389
p.I506V	EMC-BAC-2	lung	COSMIC	VTPASS	DEG_SCF_FBW7_1	0.1389
p.S526F	SIDM00217	Colorectal Carcinoma	GDSC	VTPASS	DEG_SCF_FBW7_1	0.1111
p.S526F	SNU-1040	large_intestine	COSMIC	VTPASS	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16555	Dihydropyrimidinase-related protein 2	DEG_SCF_FBW7_1	513:518	VTPASS	FBXW7	0.9996	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons