DegronMD - Q16559(TAL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q97L	TCGA-AA-A010	COAD	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.6654
p.Q97H	TCGA-B5-A0JY	UCEC	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.647
p.Q97H	DO43041	UCEC	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.647
p.S100L	TCGA-EE-A2MS	SKCM	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.8778
p.S100L	DO37567	SKCM	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.8778
p.P99S	TCGA-FW-A3R5	SKCM	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.6752
p.P99S	DO37406	SKCM	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.6752
p.E94Q	TCGA-GC-A4ZW	BLCA	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.6744
p.E94Q	DO219024	BLCA	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.6744
p.D89Y	TCGA-MI-A75C	LIHC	TCGA	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.2778
p.D89Y	DO49705	LIHC	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.2778
p.H105Y	DO234427	ESAD	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.2222
p.P103S	DO233272	GACA	ICGC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.2778
p.V98I	SIDM00954	Breast Carcinoma	GDSC	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation altering degron motif	0.7076
p.H83P	ACH-000008	Skin Cancer	CCLE	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.1111
p.H83P	ACH-000997	Colon/Colorectal Cancer	CCLE	TLLENYQVPSP	DEG_COP1_1	91:101	Mutation rewiring degron network	0.1111

Kaplan plot for TAL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAL2

UniProt ID: Q16559

Entrez ID: 6887

Protein name: T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAL2 in