DegronMD

Uniprot ID: Q16559

Source protein: T-cell acute lymphocytic leukemia protein 2

Source gene: TAL2

Class: DEG_COP1_1

Location: 91:101

E3 ligase: COP1

DEGRON score: 0.9934

ASA_SCORE: 86.9545

COIL: 0.7487

CONS_SCORE: 0.7495

DSS_SCORE: 0.622

HELIX: 0.2023

FCONS_SCORE: 1.2048

RIG_SCORE: 0.6813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q97L	TCGA-AA-A010	COAD	TCGA	TLLENYQVPSP	DEG_COP1_1	0.6654
p.Q97H	TCGA-B5-A0JY	UCEC	TCGA	TLLENYQVPSP	DEG_COP1_1	0.647
p.Q97H	DO43041	UCEC	ICGC	TLLENYQVPSP	DEG_COP1_1	0.647
p.S100L	TCGA-EE-A2MS	SKCM	TCGA	TLLENYQVPSP	DEG_COP1_1	0.8778
p.S100L	DO37567	SKCM	ICGC	TLLENYQVPSP	DEG_COP1_1	0.8778
p.P99S	TCGA-FW-A3R5	SKCM	TCGA	TLLENYQVPSP	DEG_COP1_1	0.6752
p.P99S	DO37406	SKCM	ICGC	TLLENYQVPSP	DEG_COP1_1	0.6752
p.E94Q	TCGA-GC-A4ZW	BLCA	TCGA	TLLENYQVPSP	DEG_COP1_1	0.6744
p.E94Q	DO219024	BLCA	ICGC	TLLENYQVPSP	DEG_COP1_1	0.6744
p.D89Y	TCGA-MI-A75C	LIHC	TCGA	TLLENYQVPSP	DEG_COP1_1	0.2778
p.D89Y	DO49705	LIHC	ICGC	TLLENYQVPSP	DEG_COP1_1	0.2778
p.H105Y	DO234427	ESAD	ICGC	TLLENYQVPSP	DEG_COP1_1	0.2222
p.P103S	DO233272	GACA	ICGC	TLLENYQVPSP	DEG_COP1_1	0.2778
p.V98I	SIDM00954	Breast Carcinoma	GDSC	TLLENYQVPSP	DEG_COP1_1	0.7076
p.H83P	ACH-000008	Skin Cancer	CCLE	TLLENYQVPSP	DEG_COP1_1	0.1111
p.H83P	ACH-000997	Colon/Colorectal Cancer	CCLE	TLLENYQVPSP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16559	T-cell acute lymphocytic leukemia protein 2	DEG_COP1_1	91:101	TLLENYQVPSP	COP1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons