DegronMD - Q16584(MAP3K11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R560W	TCGA-B5-A3FC	UCEC	TCGA	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.3056
p.R560W	TCGA-DF-A2KU	UCEC	TCGA	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.3056
p.R560W	DO223286	UCEC	ICGC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.3056
p.R560W	DO41871	UCEC	ICGC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.3056
p.W564L	TCGA-EE-A2GO	SKCM	TCGA	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.1944
p.S548F	TCGA-EE-A3AA	SKCM	TCGA	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation blocking phosphorylation signal	0.6111
p.S548F	DO220899	MELA	ICGC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation blocking phosphorylation signal	0.6111
p.S548F	DO222632	MELA	ICGC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation blocking phosphorylation signal	0.6111
p.S548F	DO37571	SKCM	ICGC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation blocking phosphorylation signal	0.6111
p.R550Q	TCGA-IG-A3Y9	ESCA	TCGA	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.2222
p.R561Q	SIDM00865	Small Cell Lung Carcinoma	GDSC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.2778
p.R561Q	DMS-114	lung	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.2778
p.S569T	SIDM00527	Colorectal Carcinoma	GDSC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.0556
p.S569T	MDST8	large intestine	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.0556
p.A561P	ACH-001127	Leukemia	CCLE	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.2778
p.A561P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	554:559	Mutation rewiring degron network	0.2778

Kaplan plot for MAP3K11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K11

UniProt ID: Q16584

Entrez ID: 4296

Protein name: Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K11 in