DegronMD

Uniprot ID: Q16584

Source protein: Mitogen-activated protein kinase kinase kinase 11

Source gene: MAP3K11

Class: DEG_Kelch_Keap1_1

Location: 554:559

E3 ligase: KEAP1

DEGRON score: 0.7603

ASA_SCORE: 86.6167

COIL: 0.7955

CONS_SCORE: 0.3167

DSS_SCORE: 0.5359

HELIX: 0.1758

FCONS_SCORE: 0.9428

RIG_SCORE: 0.5942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R560W	TCGA-B5-A3FC	UCEC	TCGA	DSSNGE	DEG_Kelch_Keap1_1	0.3056
p.R560W	TCGA-DF-A2KU	UCEC	TCGA	DSSNGE	DEG_Kelch_Keap1_1	0.3056
p.R560W	DO223286	UCEC	ICGC	DSSNGE	DEG_Kelch_Keap1_1	0.3056
p.R560W	DO41871	UCEC	ICGC	DSSNGE	DEG_Kelch_Keap1_1	0.3056
p.W564L	TCGA-EE-A2GO	SKCM	TCGA	DSSNGE	DEG_Kelch_Keap1_1	0.1944
p.S548F	TCGA-EE-A3AA	SKCM	TCGA	DSSNGE	DEG_Kelch_Keap1_1	0.6111
p.S548F	DO220899	MELA	ICGC	DSSNGE	DEG_Kelch_Keap1_1	0.6111
p.S548F	DO222632	MELA	ICGC	DSSNGE	DEG_Kelch_Keap1_1	0.6111
p.S548F	DO37571	SKCM	ICGC	DSSNGE	DEG_Kelch_Keap1_1	0.6111
p.R550Q	TCGA-IG-A3Y9	ESCA	TCGA	DSSNGE	DEG_Kelch_Keap1_1	0.2222
p.R561Q	SIDM00865	Small Cell Lung Carcinoma	GDSC	DSSNGE	DEG_Kelch_Keap1_1	0.2778
p.R561Q	DMS-114	lung	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	0.2778
p.S569T	SIDM00527	Colorectal Carcinoma	GDSC	DSSNGE	DEG_Kelch_Keap1_1	0.0556
p.S569T	MDST8	large_intestine	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	0.0556
p.A561P	ACH-001127	Leukemia	CCLE	DSSNGE	DEG_Kelch_Keap1_1	0.2778
p.A561P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSSNGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16584	Mitogen-activated protein kinase kinase kinase 11	DEG_Kelch_Keap1_1	554:559	DSSNGE	KEAP1	0.7603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons