DegronMD - Q16586(SGCA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P262S	TCGA-CK-4951	COAD	TCGA	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.1944
p.P262S	DO10582	COAD	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.1944
p.G265C	TCGA-D1-A16N	UCEC	TCGA	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.1111
p.G265C	DO43771	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.1111
p.G267W	TCGA-G7-6797	KIRP	TCGA	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.0556
p.G267W	DO20917	KIRP	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.0556
p.R246Q	DO222765	COCA	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.2778
p.R246Q	DO15623	HNSC	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.2778
p.R246Q	DO229054	LICA	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.2778
p.V250L	DO229015	LICA	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation altering degron motif	0.5654
p.R250L	DO23637	LUAD	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation altering degron motif	0.8428
p.R246W	DO46657	PAAD	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.2778
p.A254T	DO42336	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation altering degron motif	0.7139
p.L247M	DO42608	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.3056
p.G244C	DO41331	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.2222
p.V247M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.3056
p.V247M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TLVDKSVPEP	DEG_COP1_1	248:257	Mutation rewiring degron network	0.3056

Kaplan plot for SGCA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGCA

UniProt ID: Q16586

Entrez ID: 6442

Protein name: Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGCA in