DegronMD

Uniprot ID: Q16586

Source protein: Alpha-sarcoglycan

Source gene: SGCA

Class: DEG_COP1_1

Location: 248:257

E3 ligase: COP1

DEGRON score: 0.954

ASA_SCORE: 80.86

COIL: 0.7189

CONS_SCORE: 0.4542

DSS_SCORE: 0.3589

HELIX: 0.0175

FCONS_SCORE: 0.9917

RIG_SCORE: 0.779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P262S	TCGA-CK-4951	COAD	TCGA	TLVDKSVPEP	DEG_COP1_1	0.1944
p.P262S	DO10582	COAD	ICGC	TLVDKSVPEP	DEG_COP1_1	0.1944
p.G265C	TCGA-D1-A16N	UCEC	TCGA	TLVDKSVPEP	DEG_COP1_1	0.1111
p.G265C	DO43771	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	0.1111
p.G267W	TCGA-G7-6797	KIRP	TCGA	TLVDKSVPEP	DEG_COP1_1	0.0556
p.G267W	DO20917	KIRP	ICGC	TLVDKSVPEP	DEG_COP1_1	0.0556
p.R246Q	DO222765	COCA	ICGC	TLVDKSVPEP	DEG_COP1_1	0.2778
p.R246Q	DO15623	HNSC	ICGC	TLVDKSVPEP	DEG_COP1_1	0.2778
p.R246Q	DO229054	LICA	ICGC	TLVDKSVPEP	DEG_COP1_1	0.2778
p.V250L	DO229015	LICA	ICGC	TLVDKSVPEP	DEG_COP1_1	0.5654
p.R250L	DO23637	LUAD	ICGC	TLVDKSVPEP	DEG_COP1_1	0.8428
p.R246W	DO46657	PAAD	ICGC	TLVDKSVPEP	DEG_COP1_1	0.2778
p.A254T	DO42336	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	0.7139
p.L247M	DO42608	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	0.3056
p.G244C	DO41331	UCEC	ICGC	TLVDKSVPEP	DEG_COP1_1	0.2222
p.V247M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TLVDKSVPEP	DEG_COP1_1	0.3056
p.V247M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TLVDKSVPEP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16586	Alpha-sarcoglycan	DEG_COP1_1	248:257	TLVDKSVPEP	COP1	0.954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons