DegronMD - Q16594(TAF9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E104K	TCGA-06-5416	GBM	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.E104K	ACH-000618	Head and Neck Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R78L	TCGA-66-2789	LUSC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.R78L	DO27279	LUSC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.R89I	TCGA-AP-A0LM	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8102
p.R89I	DO43306	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8102
p.D90Y	TCGA-AZ-4315	COAD	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D90Y	TCGA-B5-A0JY	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D90Y	DO8842	COAD	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D90Y	DO43041	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.F91C	TCGA-BS-A0UV	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5996
p.F91C	DO234256	ESAD	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5996
p.F91C	DO42793	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5996
p.D80Y	TCGA-C8-A26X	BRCA	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.D80Y	DO5549	BRCA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.S82F	TCGA-EE-A2M5	SKCM	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation blocking phosphorylation signal	0.6111
p.S82F	DO222423	MELA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation blocking phosphorylation signal	0.6111
p.S82F	DO37425	SKCM	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation blocking phosphorylation signal	0.6111
p.D94Y	TCGA-EO-A22U	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D94Y	TCGA-F5-6814	READ	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D94Y	DO36556	READ	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.D94Y	DO43755	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.6214
p.R78C	DO233888	GACA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.D87Y	DO22237	LGG	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.Q90R	DO229240	THCA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R99I	SIDM01588	Endometrial Carcinoma	GDSC	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.R99I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.R87G	ACH-000899	Skin Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056

Kaplan plot for TAF9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF9

UniProt ID: Q16594

Entrez ID: 6880

Protein name: Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF9 in