DegronMD

Uniprot ID: Q16594

Source protein: Transcription initiation factor TFIID subunit 9

Source gene: TAF9

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8295

ASA_SCORE: 58.2667

COIL: 0.1562

CONS_SCORE: 0.6934

DSS_SCORE: 0.558

HELIX: 0.8413

FCONS_SCORE: 1.0624

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E104K	TCGA-06-5416	GBM	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.1111
p.E104K	ACH-000618	Head and Neck Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	0.1111
p.R78L	TCGA-66-2789	LUSC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.R78L	DO27279	LUSC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.R89I	TCGA-AP-A0LM	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.8102
p.R89I	DO43306	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.8102
p.D90Y	TCGA-AZ-4315	COAD	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D90Y	TCGA-B5-A0JY	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D90Y	DO8842	COAD	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D90Y	DO43041	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.F91C	TCGA-BS-A0UV	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.5996
p.F91C	DO234256	ESAD	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.5996
p.F91C	DO42793	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.5996
p.D80Y	TCGA-C8-A26X	BRCA	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.1111
p.D80Y	DO5549	BRCA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.1111
p.S82F	TCGA-EE-A2M5	SKCM	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.S82F	DO222423	MELA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.S82F	DO37425	SKCM	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.D94Y	TCGA-EO-A22U	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D94Y	TCGA-F5-6814	READ	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D94Y	DO36556	READ	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.D94Y	DO43755	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6214
p.R78C	DO233888	GACA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.D87Y	DO22237	LGG	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.3056
p.Q90R	DO229240	THCA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.7329
p.R99I	SIDM01588	Endometrial Carcinoma	GDSC	PRDFLLDIA	DEG_APCC_DBOX_1	0.25
p.R99I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	0.25
p.R87G	ACH-000899	Skin Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16594	Transcription initiation factor TFIID subunit 9	DEG_APCC_DBOX_1	88:96	PRDFLLDIA	APC,CDC20,FZR1	0.8295	More...
Q9HBM6	Transcription initiation factor TFIID subunit 9B	DEG_APCC_DBOX_1	88:96	PRDFLLDIA	APC,CDC20,FZR1	0.9575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRDFLLDIA

Degron related mutations and impact score

Drug responses associated with TAF9 mutations

All proteins holding degron of PRDFLLDIA