DegronMD

Uniprot ID: Q9HBM6

Source protein: Transcription initiation factor TFIID subunit 9B

Source gene: TAF9B

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9575

ASA_SCORE: 55.5778

COIL: 0.2182

CONS_SCORE: 0.6887

DSS_SCORE: 0.5509

HELIX: 0.776

FCONS_SCORE: 1.046

RIG_SCORE: 0.795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R78S	TCGA-AP-A1E0	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.R78S	DO43154	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.S82Y	TCGA-BS-A0UF	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.S82Y	DO229029	LICA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.S82Y	DO41488	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.D90N	TCGA-QF-A5YS	UCEC	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.5821
p.D90N	DO52426	UCEC	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.5821
p.A96T	TCGA-YU-A94I	TGCT	TCGA	PRDFLLDIA	DEG_APCC_DBOX_1	0.6028
p.A96T	DO228581	GACA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6028
p.A79V	DO233260	GACA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0833
p.Q98H	DO228938	LICA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.2778
p.T102I	DO229234	THCA	ICGC	PRDFLLDIA	DEG_APCC_DBOX_1	0.6111
p.P88Q	SIDM01483	Melanoma	GDSC	PRDFLLDIA	DEG_APCC_DBOX_1	0.5924
p.P88Q	ACH-000582	Skin Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	0.5924
p.P88Q	COLO-741	large_intestine	COSMIC	PRDFLLDIA	DEG_APCC_DBOX_1	0.5924
p.R78H	SIDM00602	Gastric Carcinoma	GDSC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.R78H	ACH-000919	Gastric Cancer	CCLE	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556
p.R78H	IM-95	stomach	COSMIC	PRDFLLDIA	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16594	Transcription initiation factor TFIID subunit 9	DEG_APCC_DBOX_1	88:96	PRDFLLDIA	APC,CDC20,FZR1	0.8295	More...
Q9HBM6	Transcription initiation factor TFIID subunit 9B	DEG_APCC_DBOX_1	88:96	PRDFLLDIA	APC,CDC20,FZR1	0.9575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons