DegronMD - Q16612(NREP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y47S	TCGA-DK-AA77	BLCA	TCGA	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2778
p.Y48S	TCGA-FI-A2D5	UCEC	TCGA	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.3056
p.E43G	DO229010	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.E43G	DO229013	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.E43G	DO229005	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.E43G	DO228947	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.E43G	DO52365	LUSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.R58C	DO14338	HNSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2222
p.R58L	DO229015	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2222
p.L43Q	DO23302	LINC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1667
p.G53S	DO37655	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation altering degron motif	0.5882
p.D42N	DO37814	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1389
p.R61K	DO43186	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1389
p.R61I	DO43154	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.1389
p.G53D	DO42568	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation altering degron motif	0.6087
p.V46G	SIDM01018	Hodgkin's Lymphoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.25
p.V46G	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.25
p.R58H	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2222
p.R58H	RKO	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2222
p.R58S	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	49:54	Mutation rewiring degron network	0.2222

Kaplan plot for NREP in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NREP

UniProt ID: Q16612

Entrez ID: 9315

Protein name: Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NREP in