DegronMD

Uniprot ID: Q16612

Source protein: Neuronal regeneration-related protein

Source gene: NREP

Class: DEG_SCF_FBW7_1

Location: 49:54

E3 ligase: FBXW7

DEGRON score: 0.8141

ASA_SCORE: 46.9833

COIL: 0.6787

CONS_SCORE: 0.6837

DSS_SCORE: 0.511

HELIX: 0.0373

FCONS_SCORE: 1.0216

RIG_SCORE: 0.6946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y47S	TCGA-DK-AA77	BLCA	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.2778
p.Y48S	TCGA-FI-A2D5	UCEC	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.E43G	DO229010	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.E43G	DO229013	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.E43G	DO229005	COCA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.E43G	DO228947	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.E43G	DO52365	LUSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.R58C	DO14338	HNSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.2222
p.R58L	DO229015	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.2222
p.L43Q	DO23302	LINC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.G53S	DO37655	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.5882
p.D42N	DO37814	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1389
p.R61K	DO43186	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1389
p.R61I	DO43154	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.1389
p.G53D	DO42568	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.6087
p.V46G	SIDM01018	Hodgkin's Lymphoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	0.25
p.V46G	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.25
p.R58H	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.2222
p.R58H	RKO	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.2222
p.R58S	ACH-000943	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SCF_FBW7_1	1170:1175	LTPLGS	FBXW7	0.9627	More...
Q16612	Neuronal regeneration-related protein	DEG_SCF_FBW7_1	49:54	LTPLGS	FBXW7	0.8141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons