DegronMD - Q13332(PTPRS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1342T	TCGA-69-7980	LUAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.3056
p.R1342T	TCGA-69-7980	LUAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1111
p.E717K	TCGA-A6-6653	COAD	TCGA	TDEDVPSA	DEG_COP1_1	715:722	Mutation altering degron motif	0.591
p.E717K	TCGA-VS-A9UD	CESC	TCGA	TDEDVPSA	DEG_COP1_1	715:722	Mutation altering degron motif	0.591
p.R1320H	TCGA-AA-3815	COAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320H	TCGA-HU-A4GU	STAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1165H	TCGA-AG-A011	READ	TCGA	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.1944
p.R1343C	TCGA-AX-A0J1	UCEC	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.R1343C	TCGA-AX-A0J1	UCEC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1389
p.T1348I	TCGA-BR-8372	STAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.1389
p.T1348I	TCGA-BR-8372	STAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.T1348I	DO47873	STAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.1389
p.T1348I	DO47873	STAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.K669N	TCGA-BR-8487	STAD	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation substituting flanking lysine	0.2778
p.E687Q	TCGA-C5-A7UH	CESC	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1111
p.F1346L	TCGA-D1-A16J	UCEC	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.1944
p.F1346L	TCGA-D1-A16J	UCEC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.R1343H	TCGA-D5-6930	COAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.R1343H	TCGA-D5-6930	COAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1389
p.P1172S	TCGA-D6-6516	HNSC	TCGA	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.6752
p.P666S	TCGA-EB-A85J	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0833
p.P675L	TCGA-EE-A2A2	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7582
p.P1360L	TCGA-EP-A2KA	LIHC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1944
p.I674T	TCGA-F1-6874	STAD	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.3056
p.V832L	TCGA-FS-A1ZG	SKCM	TCGA	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.1111
p.P1172Q	TCGA-GN-A265	SKCM	TCGA	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.7035
p.G673C	TCGA-GN-A26D	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2778
p.D1178N	TCGA-L5-A4OP	ESCA	TCGA	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.25
p.R851C	TCGA-RD-A7C1	STAD	TCGA	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.2222
p.R851C	DO50132	STAD	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.2222
p.D1337N	TCGA-WE-A8K4	SKCM	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.5821
p.D716N	TCGA-XF-AAMG	BLCA	TCGA	TDEDVPSA	DEG_COP1_1	715:722	Mutation altering degron motif	0.6932
p.D712N	DO219049	BLCA	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.25
p.D712N	DO233944	GACA	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.25
p.G857D	DO1010	BRCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.0556
p.E713K	DO219733	CESC	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.2778
p.E713K	DO10373	COAD	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.2778
p.E683Q	DO49891	CESC	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2222
p.R1184Q	DO49929	CESC	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.0833
p.R1184Q	DO8447	COAD	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.0833
p.R1321H	DO10550	COAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0833
p.R1321H	DO233693	GACA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0833
p.R1321H	DO233855	GACA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0833
p.T1344M	DO10349	COAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.25
p.T1344M	DO10349	COAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1667
p.A1356T	DO8384	COAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.3056
p.A1356T	DO43506	UCEC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.3056
p.R852H	DO234378	ESAD	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.1944
p.G1168D	DO234467	ESAD	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.2778
p.Q1357K	DO233280	GACA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.Q1357K	DO228952	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.Q1357K	DO228978	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2778
p.P1168S	DO15623	HNSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.2778
p.T711I	DO228974	LICA	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.2222
p.Q1168K	DO229027	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.2778
p.T1362K	DO229027	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1389
p.H1335N	DO229008	LICA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.7423
p.P1361L	DO23023	LIHC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1667
p.R1338T	DO23678	LUAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.7876
p.P720L	DO228338	MALY	ICGC	TDEDVPSA	DEG_COP1_1	715:722	Mutation altering degron motif	0.7582
p.G1362E	DO50660	ORCA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1389
p.L838R	DO229453	SKCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.2778
p.P671L	DO37583	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2222
p.P1354S	DO37819	SKCM	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.6752
p.G669C	DO37480	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation substituting flanking lysine	0.2778
p.P1173Q	DO37491	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.7035
p.R689S	DO50279	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0556
p.D1338N	DO51281	SKCM	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.6932
p.K665N	DO47867	STAD	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0556
p.P1351L	DO47867	STAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.7582
p.I670T	DO38201	STAD	ICGC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.R1359G	DO229259	THCA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.2222
p.Q842H	DO229272	THCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation altering degron motif	0.647
p.P844S	DO229242	THCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation altering degron motif	0.6752
p.R1172H	DO43098	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.8244
p.F1342L	DO43033	UCEC	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.3056
p.F1342L	DO43033	UCEC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1111
p.R1339C	DO41199	UCEC	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.8301
p.S839L	SIDM00193	Colorectal Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.3056
p.S839L	SIDM00732	Glioblastoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.3056
p.F1169V	SIDM00832	Colorectal Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.F1169V	ACH-000680	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.F1169V	SW948	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.R1162C	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.1111
p.R1162C	ACH-000334	Lymphoma	CCLE	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.1111
p.R1162C	DB	haematopoietic and lymphoid tissue	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.1111
p.R1320C	SIDM00853	Other Sarcomas	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320C	SIDM00217	Colorectal Carcinoma	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320C	ACH-000835	Sarcoma	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320C	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320C	SNU-1040	large intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.R1320C	GCT	soft tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.A1328T	SIDM00290	Gastric Carcinoma	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.A1328T	ACH-000847	Gastric Cancer	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.A1328T	HGC-27	stomach	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.F1169L	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.F1169L	ACH-000109	Lung Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.F1169L	H3255	lung	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.E845Q	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation altering degron motif	0.5633
p.E845Q	SIDM00169	Head and Neck Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation altering degron motif	0.5633
p.I1344V	SIDM00462	Acute Myeloid Leukemia	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.25
p.I1344V	SIDM00462	Acute Myeloid Leukemia	GDSC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1667
p.I1344V	ACH-000336	Leukemia	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.25
p.I1344V	ACH-000336	Leukemia	CCLE	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1667
p.I1344V	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.25
p.I1344V	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1667
p.D1350Y	SIDM00150	Colorectal Carcinoma	GDSC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.7325
p.D1350Y	KM12	large intestine	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.7325
p.P855L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.1111
p.P855L	ACH-000925	Lung Cancer	CCLE	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.1111
p.L1184P	SIDM01450	Gastric Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.0833
p.M1179I	ACH-000677	Lung Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.2222
p.E717D	ACH-001610	Brain Cancer	CCLE	TDEDVPSA	DEG_COP1_1	715:722	Mutation altering degron motif	0.5647
p.P723S	ACH-002508	Skin Cancer	CCLE	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.3056
p.R731C	DB	haematopoietic and lymphoid tissue	COSMIC	TDEDVPSA	DEG_COP1_1	715:722	Mutation rewiring degron network	0.0833
p.N670S	IGROV-1	ovary	COSMIC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.V1174A	AN3-CA	endometrium	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.6936
p.F666L	EKVX	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0833
p.R1181C	SNU-1040	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.1667
p.V1178A	AN3-CA	endometrium	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.25
p.E1350K	SW1783	central nervous system	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.7022
p.M1324I	GP5d	large intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.1667
p.G1339V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.7532
p.D1169N	SNU-1040	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.3056
p.I1322V	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation blocking ubiquitination signal	0.5556
p.N689T	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0556
p.F670L	EKVX	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.G1343V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.G1343V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation rewiring degron network	0.1389
p.M1320I	GP5d	large intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.0556
p.G1328C	KM12	large intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.2778
p.A1341V	TGBC11TKB	stomach	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation altering degron motif	0.6936
p.G857E	SNU-1040	large intestine	COSMIC	VQQTPEGS	DEG_SCF_FBW7_1	840:847	Mutation rewiring degron network	0.0556
p.R1323C	CL-34	large intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	1330:1341	Mutation rewiring degron network	0.1389
p.E1354K	SW1783	central nervous system	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	1350:1355	Mutation altering degron motif	0.7022
p.N674S	IGROV-1	ovary	COSMIC	PPTTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.3056
p.D1173N	SNU-1040	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation altering degron motif	0.6932
p.R1185C	SNU-1040	large intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	1170:1175	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRS

UniProt ID: Q13332

Entrez ID: 5802

Protein name: Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRS in