DegronMD

Uniprot ID: Q13332

Source protein: Receptor-type tyrosine-protein phosphatase S

Source gene: PTPRS

Class: DEG_ODPH_VHL_1

Location: 1330:1341

E3 ligase: VHL

DEGRON score: 0.9191

ASA_SCORE: 83.2333

COIL: 0.7724

CONS_SCORE: 0.5822

DSS_SCORE: 0.5625

HELIX: 0.1845

FCONS_SCORE: 1.003

RIG_SCORE: 0.6667

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1342T	TCGA-69-7980	LUAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.3056
p.R1320H	TCGA-AA-3815	COAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320H	TCGA-HU-A4GU	STAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1343C	TCGA-AX-A0J1	UCEC	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.T1348I	TCGA-BR-8372	STAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.1389
p.T1348I	DO47873	STAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.1389
p.F1346L	TCGA-D1-A16J	UCEC	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.1944
p.R1343H	TCGA-D5-6930	COAD	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.D1337N	TCGA-WE-A8K4	SKCM	TCGA	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.5821
p.R1321H	DO10550	COAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0833
p.R1321H	DO233693	GACA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0833
p.R1321H	DO233855	GACA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0833
p.T1344M	DO10349	COAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.25
p.H1335N	DO229008	LICA	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.7423
p.R1338T	DO23678	LUAD	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.7876
p.D1338N	DO51281	SKCM	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.6932
p.F1342L	DO43033	UCEC	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.3056
p.R1339C	DO41199	UCEC	ICGC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.8301
p.R1320C	SIDM00853	Other Sarcomas	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320C	SIDM00217	Colorectal Carcinoma	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320C	ACH-000835	Sarcoma	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320C	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320C	SNU-1040	large_intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.R1320C	GCT	soft_tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.A1328T	SIDM00290	Gastric Carcinoma	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.A1328T	ACH-000847	Gastric Cancer	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.A1328T	HGC-27	stomach	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.I1344V	SIDM00462	Acute Myeloid Leukemia	GDSC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.25
p.I1344V	ACH-000336	Leukemia	CCLE	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.25
p.I1344V	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.25
p.M1324I	GP5d	large_intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.1667
p.G1339V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.7532
p.I1322V	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.5556
p.G1343V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.M1320I	GP5d	large_intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.0556
p.G1328C	KM12	large_intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.2778
p.A1341V	TGBC11TKB	stomach	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.6936
p.R1323C	CL-34	large_intestine	COSMIC	LAPHHPKDPVEM	DEG_ODPH_VHL_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPHHPKDPVEM

Degron related mutations and impact score

Drug responses associated with PTPRS mutations

All proteins holding degron of LAPHHPKDPVEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_ODPH_VHL_1	1330:1341	LAPHHPKDPVEM	VHL	0.9191	More...