DegronMD

Uniprot ID: Q13332

Source protein: Receptor-type tyrosine-protein phosphatase S

Source gene: PTPRS

Class: DEG_SCF_TRCP1_1

Location: 1350:1355

E3 ligase: BTRC

DEGRON score: 0.9658

ASA_SCORE: 80.0333

COIL: 0.9003

CONS_SCORE: 0.539

DSS_SCORE: 0.5754

HELIX: 0.0587

FCONS_SCORE: 0.9773

RIG_SCORE: 0.6361

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1342T	TCGA-69-7980	LUAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.1111
p.R1343C	TCGA-AX-A0J1	UCEC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.1389
p.T1348I	TCGA-BR-8372	STAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.2778
p.T1348I	DO47873	STAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.2778
p.F1346L	TCGA-D1-A16J	UCEC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.2222
p.R1343H	TCGA-D5-6930	COAD	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.1389
p.P1360L	TCGA-EP-A2KA	LIHC	TCGA	DSGLRS	DEG_SCF_TRCP1_1	0.1944
p.T1344M	DO10349	COAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.1667
p.A1356T	DO8384	COAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.3056
p.A1356T	DO43506	UCEC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.3056
p.Q1357K	DO233280	GACA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.2778
p.Q1357K	DO228952	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.2778
p.Q1357K	DO228978	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.2778
p.T1362K	DO229027	LICA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.1389
p.P1361L	DO23023	LIHC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.1667
p.G1362E	DO50660	ORCA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.1389
p.P1354S	DO37819	SKCM	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.6752
p.P1351L	DO47867	STAD	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.7582
p.R1359G	DO229259	THCA	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.2222
p.F1342L	DO43033	UCEC	ICGC	DSGLRS	DEG_SCF_TRCP1_1	0.1111
p.I1344V	SIDM00462	Acute Myeloid Leukemia	GDSC	DSGLRS	DEG_SCF_TRCP1_1	0.1667
p.I1344V	ACH-000336	Leukemia	CCLE	DSGLRS	DEG_SCF_TRCP1_1	0.1667
p.I1344V	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	0.1667
p.D1350Y	SIDM00150	Colorectal Carcinoma	GDSC	DSGLRS	DEG_SCF_TRCP1_1	0.7325
p.D1350Y	KM12	large_intestine	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	0.7325
p.E1350K	SW1783	central_nervous_system	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	0.7022
p.G1343V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	0.1389
p.E1354K	SW1783	central_nervous_system	COSMIC	DSGLRS	DEG_SCF_TRCP1_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGLRS

Degron related mutations and impact score

Drug responses associated with PTPRS mutations

All proteins holding degron of DSGLRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SCF_TRCP1_1	1350:1355	DSGLRS	BTRC	0.9658	More...