DegronMD

Uniprot ID: Q13332

Source protein: Receptor-type tyrosine-protein phosphatase S

Source gene: PTPRS

Class: DEG_SCF_FBW7_1

Location: 1170:1175

E3 ligase: FBXW7

DEGRON score: 0.9627

ASA_SCORE: 51.1167

COIL: 0.707

CONS_SCORE: 0.5696

DSS_SCORE: 0.4658

HELIX: 0.0167

FCONS_SCORE: 0.9451

RIG_SCORE: 0.7029

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1165H	TCGA-AG-A011	READ	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.1944
p.P1172S	TCGA-D6-6516	HNSC	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.6752
p.P1172Q	TCGA-GN-A265	SKCM	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.7035
p.D1178N	TCGA-L5-A4OP	ESCA	TCGA	LTPLGS	DEG_SCF_FBW7_1	0.25
p.R1184Q	DO49929	CESC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.0833
p.R1184Q	DO8447	COAD	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.0833
p.G1168D	DO234467	ESAD	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.2778
p.P1168S	DO15623	HNSC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.2778
p.Q1168K	DO229027	LICA	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.2778
p.P1173Q	DO37491	SKCM	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.7035
p.R1172H	DO43098	UCEC	ICGC	LTPLGS	DEG_SCF_FBW7_1	0.8244
p.F1169V	SIDM00832	Colorectal Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.F1169V	ACH-000680	Colon/Colorectal Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.F1169V	SW948	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.R1162C	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	0.1111
p.R1162C	ACH-000334	Lymphoma	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.1111
p.R1162C	DB	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.1111
p.F1169L	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.F1169L	ACH-000109	Lung Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.F1169L	H3255	lung	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.L1184P	SIDM01450	Gastric Carcinoma	GDSC	LTPLGS	DEG_SCF_FBW7_1	0.0833
p.M1179I	ACH-000677	Lung Cancer	CCLE	LTPLGS	DEG_SCF_FBW7_1	0.2222
p.V1174A	AN3-CA	endometrium	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.6936
p.R1181C	SNU-1040	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.1667
p.V1178A	AN3-CA	endometrium	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.25
p.D1169N	SNU-1040	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.3056
p.D1173N	SNU-1040	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.6932
p.R1185C	SNU-1040	large_intestine	COSMIC	LTPLGS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SCF_FBW7_1	1170:1175	LTPLGS	FBXW7	0.9627	More...
Q16612	Neuronal regeneration-related protein	DEG_SCF_FBW7_1	49:54	LTPLGS	FBXW7	0.8141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLGS

Degron related mutations and impact score

Drug responses associated with PTPRS mutations

All proteins holding degron of LTPLGS