DegronMD

Uniprot ID: Q13332

Source protein: Receptor-type tyrosine-protein phosphatase S

Source gene: PTPRS

Class: DEG_COP1_1

Location: 715:722

E3 ligase: COP1

DEGRON score: 0.9981

ASA_SCORE: 70.375

COIL: 0.8528

CONS_SCORE: 0.7243

DSS_SCORE: 0.5603

HELIX: 0.0202

FCONS_SCORE: 1.1372

RIG_SCORE: 0.7075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E717K	TCGA-A6-6653	COAD	TCGA	TDEDVPSA	DEG_COP1_1	0.591
p.E717K	TCGA-VS-A9UD	CESC	TCGA	TDEDVPSA	DEG_COP1_1	0.591
p.D716N	TCGA-XF-AAMG	BLCA	TCGA	TDEDVPSA	DEG_COP1_1	0.6932
p.D712N	DO219049	BLCA	ICGC	TDEDVPSA	DEG_COP1_1	0.25
p.D712N	DO233944	GACA	ICGC	TDEDVPSA	DEG_COP1_1	0.25
p.E713K	DO219733	CESC	ICGC	TDEDVPSA	DEG_COP1_1	0.2778
p.E713K	DO10373	COAD	ICGC	TDEDVPSA	DEG_COP1_1	0.2778
p.T711I	DO228974	LICA	ICGC	TDEDVPSA	DEG_COP1_1	0.2222
p.P720L	DO228338	MALY	ICGC	TDEDVPSA	DEG_COP1_1	0.7582
p.E717D	ACH-001610	Brain Cancer	CCLE	TDEDVPSA	DEG_COP1_1	0.5647
p.P723S	ACH-002508	Skin Cancer	CCLE	TDEDVPSA	DEG_COP1_1	0.3056
p.R731C	DB	haematopoietic_and_lymphoid_tissue	COSMIC	TDEDVPSA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_COP1_1	715:722	TDEDVPSA	COP1	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons