DegronMD

Uniprot ID: Q13332

Source protein: Receptor-type tyrosine-protein phosphatase S

Source gene: PTPRS

Class: DEG_SCF_FBW7_1

Location: 840:847

E3 ligase: FBXW7

DEGRON score: 0.6668

ASA_SCORE: 60.45

COIL: 0.4145

CONS_SCORE: 0.5647

DSS_SCORE: 0.4891

HELIX: 0.01

FCONS_SCORE: 0.9126

RIG_SCORE: 0.7342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V832L	TCGA-FS-A1ZG	SKCM	TCGA	VQQTPEGS	DEG_SCF_FBW7_1	0.1111
p.R851C	TCGA-RD-A7C1	STAD	TCGA	VQQTPEGS	DEG_SCF_FBW7_1	0.2222
p.R851C	DO50132	STAD	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.2222
p.G857D	DO1010	BRCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.0556
p.R852H	DO234378	ESAD	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.1944
p.L838R	DO229453	SKCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.2778
p.Q842H	DO229272	THCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.647
p.P844S	DO229242	THCA	ICGC	VQQTPEGS	DEG_SCF_FBW7_1	0.6752
p.S839L	SIDM00193	Colorectal Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	0.3056
p.S839L	SIDM00732	Glioblastoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	0.3056
p.E845Q	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	0.5633
p.E845Q	SIDM00169	Head and Neck Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	0.5633
p.P855L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VQQTPEGS	DEG_SCF_FBW7_1	0.1111
p.P855L	ACH-000925	Lung Cancer	CCLE	VQQTPEGS	DEG_SCF_FBW7_1	0.1111
p.G857E	SNU-1040	large_intestine	COSMIC	VQQTPEGS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13332	Receptor-type tyrosine-protein phosphatase S	DEG_SCF_FBW7_1	840:847	VQQTPEGS	FBXW7	0.6668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons