DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VQQTPEGS
Uniprot ID:
Q13332
Source protein:
Receptor-type tyrosine-protein phosphatase S
Source gene:
PTPRS
Class:
DEG_SCF_FBW7_1
Location:
840:847
E3 ligase:
FBXW7
DEGRON score:
0.6668
ASA_SCORE:
60.45
COIL:
0.4145
CONS_SCORE:
0.5647
DSS_SCORE:
0.4891
HELIX:
0.01
FCONS_SCORE:
0.9126
RIG_SCORE:
0.7342
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P844S
DO229242
THCA
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.6752
p.Q842H
DO229272
THCA
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.647
p.E845Q
SIDM00526
Chronic Myelogenous Leukemia
GDSC
VQQTPEGS
DEG_SCF_FBW7_1
0.5633
p.E845Q
SIDM00169
Head and Neck Carcinoma
GDSC
VQQTPEGS
DEG_SCF_FBW7_1
0.5633
p.S839L
SIDM00193
Colorectal Carcinoma
GDSC
VQQTPEGS
DEG_SCF_FBW7_1
0.3056
p.S839L
SIDM00732
Glioblastoma
GDSC
VQQTPEGS
DEG_SCF_FBW7_1
0.3056
p.L838R
DO229453
SKCA
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.2778
p.R851C
TCGA-RD-A7C1
STAD
TCGA
VQQTPEGS
DEG_SCF_FBW7_1
0.2222
p.R851C
DO50132
STAD
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.2222
p.R852H
DO234378
ESAD
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.1944
p.V832L
TCGA-FS-A1ZG
SKCM
TCGA
VQQTPEGS
DEG_SCF_FBW7_1
0.1111
p.P855L
SIDM01510
Non-Small Cell Lung Carcinoma
GDSC
VQQTPEGS
DEG_SCF_FBW7_1
0.1111
p.P855L
ACH-000925
Lung Cancer
CCLE
VQQTPEGS
DEG_SCF_FBW7_1
0.1111
p.G857D
DO1010
BRCA
ICGC
VQQTPEGS
DEG_SCF_FBW7_1
0.0556
p.G857E
SNU-1040
large_intestine
COSMIC
VQQTPEGS
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with PTPRS mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VQQTPEGS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13332
Receptor-type tyrosine-protein phosphatase S
DEG_SCF_FBW7_1
840:847
VQQTPEGS
FBXW7
0.6668
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