DegronMD - Q16620(NTRK2)

GO - Biological processes (BP): brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to amino acid stimulus [GO:0071230]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to nerve growth factor stimulus [GO:1990090]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; circadian rhythm [GO:0007623]; feeding behavior [GO:0007631]; glutamate secretion [GO:0014047]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; mechanoreceptor differentiation [GO:0042490]; myelination in peripheral nervous system [GO:0022011]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of anoikis [GO:2000811]; negative regulation of neuron apoptotic process [GO:0043524]; neuronal action potential propagation [GO:0019227]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; oligodendrocyte differentiation [GO:0048709]; peripheral nervous system neuron development [GO:0048935]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of GTPase activity [GO:0043087]; regulation of protein kinase B signaling [GO:0051896]; retinal rod cell development [GO:0046548]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]; trans-synaptic signaling by neuropeptide, modulating synaptic transmission [GO:0099551]; vasculogenesis [GO:0001570] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S257F	TCGA-AA-A010	COAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation blocking phosphorylation signal	0.7222
p.N254S	TCGA-AG-3892	READ	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.N254S	DO36394	READ	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.N270H	TCGA-AP-A1DV	UCEC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.N270H	DO43186	UCEC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1944
p.A268V	TCGA-BR-8284	STAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.A268V	TCGA-BR-8680	STAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.A268V	TCGA-EP-A2KA	LIHC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.A268V	DO23023	LIHC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.A268V	DO38491	STAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.A268V	DO47769	STAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.25
p.I264F	TCGA-CK-4951	COAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.6304
p.I264F	DO10582	COAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.6304
p.I264M	TCGA-CN-4729	HNSC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.6507
p.I264M	DO16029	HNSC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.6507
p.D259G	TCGA-CV-A6JD	HNSC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.7198
p.D259G	DO49035	HNSC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.7198
p.V267A	TCGA-FI-A2D0	UCEC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.V267A	DO43891	UCEC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.2778
p.S265Y	TCGA-MP-A4T4	LUAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.712
p.S265Y	DO45357	LUAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.712
p.K262N	DO229019	LICA	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation altering degron motif	0.5806
p.V272L	DO229034	LICA	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.1389
p.D258N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.3056
p.D258N	ACH-002256	Leukemia	CCLE	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.3056
p.D258N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGKQIS	DEG_SCF_TRCP1_1	259:265	Mutation rewiring degron network	0.3056

Kaplan plot for NTRK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NTRK2

UniProt ID: Q16620

Entrez ID: 4915

Protein name: BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NTRK2 in