DegronMD

Uniprot ID: Q16620

Source protein: BDNF/NT-3 growth factors receptor

Source gene: NTRK2

Class: DEG_SCF_TRCP1_1

Location: 259:265

E3 ligase: BTRC

DEGRON score: 0.9478

ASA_SCORE: 49.9571

COIL: 0.5794

CONS_SCORE: 0.4581

DSS_SCORE: 0.3606

HELIX: 0.0403

FCONS_SCORE: 0.9012

RIG_SCORE: 0.721

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S257F	TCGA-AA-A010	COAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.7222
p.N254S	TCGA-AG-3892	READ	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.1944
p.N254S	DO36394	READ	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.1944
p.N270H	TCGA-AP-A1DV	UCEC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.1944
p.N270H	DO43186	UCEC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.1944
p.A268V	TCGA-BR-8284	STAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.A268V	TCGA-BR-8680	STAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.A268V	TCGA-EP-A2KA	LIHC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.A268V	DO23023	LIHC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.A268V	DO38491	STAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.A268V	DO47769	STAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.25
p.I264F	TCGA-CK-4951	COAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.6304
p.I264F	DO10582	COAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.6304
p.I264M	TCGA-CN-4729	HNSC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.6507
p.I264M	DO16029	HNSC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.6507
p.D259G	TCGA-CV-A6JD	HNSC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.7198
p.D259G	DO49035	HNSC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.7198
p.V267A	TCGA-FI-A2D0	UCEC	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.2778
p.V267A	DO43891	UCEC	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.2778
p.S265Y	TCGA-MP-A4T4	LUAD	TCGA	DSGKQIS	DEG_SCF_TRCP1_1	0.712
p.S265Y	DO45357	LUAD	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.712
p.K262N	DO229019	LICA	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.5806
p.V272L	DO229034	LICA	ICGC	DSGKQIS	DEG_SCF_TRCP1_1	0.1389
p.D258N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGKQIS	DEG_SCF_TRCP1_1	0.3056
p.D258N	ACH-002256	Leukemia	CCLE	DSGKQIS	DEG_SCF_TRCP1_1	0.3056
p.D258N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGKQIS	DEG_SCF_TRCP1_1	0.3056

Drug responses associated with NTRK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K308Q (No)	GDSC	WZ3105	0.696
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K308Q (No)	GDSC	Lestaurtinib	4.3763
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K308Q (No)	GDSC	AZD1332	9.762
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K308Q (No)	GDSC	AZD1332	203.97
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.L138F (No)	GDSC	WZ3105	25.4931
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.L138F (No)	GDSC	Lestaurtinib	0.6035
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.L138F (No)	GDSC	AZD1332	4.8769
SIDM00305	OV\|ovary	p.A314V (No)	GDSC	WZ3105	36.8108
SIDM00305	OV\|ovary	p.A314V (No)	GDSC	Lestaurtinib	0.2579
SIDM00305	OV\|ovary	p.A314V (No)	GDSC	AZD1332	11.39
SIDM00572	STAD\|stomach	p.L584M (No)	GDSC	WZ3105	2.4062
SIDM00572	STAD\|stomach	p.L584M (No)	GDSC	Lestaurtinib	1.4729
SIDM00572	STAD\|stomach	p.L584M (No)	GDSC	AZD1332	7.3399
SIDM00572	STAD\|stomach	p.L584M (No)	GDSC	AZD1332	74.051
SIDM00213	THCA\|thyroid	p.V622I (No)	GDSC	WZ3105	27.4792
SIDM00213	THCA\|thyroid	p.V622I (No)	GDSC	Lestaurtinib	0.1665
SIDM00213	THCA\|thyroid	p.V622I (No)	GDSC	AZD1332	12.3139
SIDM00213	THCA\|thyroid	p.V622I (No)	GDSC	AZD1332	18.732
SIDM01086	ALL\|leukemia	p.R14W (No)	GDSC	WZ3105	0.0607
SIDM01086	ALL\|leukemia	p.R14W (No)	GDSC	Lestaurtinib	0.0672
SIDM01086	ALL\|leukemia	p.R14W (No)	GDSC	AZD1332	11.3231
SIDM01086	ALL\|leukemia	p.R14W (No)	GDSC	AZD1332	51.593
SIDM00874	BRCA\|breast	p.Q531E (No)	GDSC	WZ3105	0.2733
SIDM00874	BRCA\|breast	p.Q531E (No)	GDSC	Lestaurtinib	3.4269
SIDM00874	BRCA\|breast	p.Q531E (No)	GDSC	AZD1332	10.4633
SIDM00874	BRCA\|breast	p.Q531E (No)	GDSC	AZD1332	316.47
SIDM00959	LAML\|acute_myeloid_leukaemia	p.K551R (No)	GDSC	WZ3105	0.4498
SIDM00959	LAML\|acute_myeloid_leukaemia	p.K551R (No)	GDSC	Lestaurtinib	0.2039
SIDM00959	LAML\|acute_myeloid_leukaemia	p.K551R (No)	GDSC	AZD1332	9.8588
SIDM01007	ALL\|lymphoblastic_leukemia	p.D258N (Yes)	GDSC	WZ3105	0.0937
SIDM01007	ALL\|lymphoblastic_leukemia	p.D258N (Yes)	GDSC	Lestaurtinib	0.0695
SIDM01007	ALL\|lymphoblastic_leukemia	p.D258N (Yes)	GDSC	AZD1332	16.6738
SIDM01007	ALL\|lymphoblastic_leukemia	p.D258N (Yes)	GDSC	AZD1332	28.554
SIDM00003	SKCM\|melanoma	p.P507L (No)	GDSC	WZ3105	11.6994
SIDM00003	SKCM\|melanoma	p.P507L (No)	GDSC	Lestaurtinib	0.0586
SIDM00003	SKCM\|melanoma	p.P507L (No)	GDSC	AZD1332	12.4049
SIDM00003	SKCM\|melanoma	p.P507L (No)	GDSC	AZD1332	187.21
SIDM00157	NB\|neuroblastoma	p.L584F (No)	GDSC	WZ3105	0.5334
SIDM00157	NB\|neuroblastoma	p.L584F (No)	GDSC	Lestaurtinib	0.6848
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.A586V (No)	GDSC	WZ3105	0.2291
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.A586V (No)	GDSC	Lestaurtinib	1.5364
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.A586V (No)	GDSC	AZD1332	32.3306
SIDM00495	DLBC\|B_cell_lymphoma	p.R42G (No)	GDSC	WZ3105	0.3707
SIDM00495	DLBC\|B_cell_lymphoma	p.R42G (No)	GDSC	Lestaurtinib	0.0847
SIDM00495	DLBC\|B_cell_lymphoma	p.R42G (No)	GDSC	AZD1332	3.9369
SIDM00495	DLBC\|B_cell_lymphoma	p.R42G (No)	GDSC	AZD1332	10.285
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V422L (No)	GDSC	WZ3105	53.2606
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V422L (No)	GDSC	Lestaurtinib	5.6144
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V422L (No)	GDSC	AZD1332	3.0986
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V422L (No)	GDSC	AZD1332	43.946
SIDM00660	COREAD\|large_intestine	p.K814R (No)	GDSC	WZ3105	0.3902
SIDM00660	COREAD\|large_intestine	p.K814R (No)	GDSC	Lestaurtinib	0.3509
SIDM00660	COREAD\|large_intestine	p.K814R (No)	GDSC	AZD1332	4.1424
SIDM00660	COREAD\|large_intestine	p.K814R (No)	GDSC	AZD1332	96.184
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.L140F (No)	GDSC	WZ3105	0.5586
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.L140F (No)	GDSC	Lestaurtinib	0.5359
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.L140F (No)	GDSC	AZD1332	8.3204
SIDM00340	MM\|myeloma	p.A11P (No)	GDSC	WZ3105	0.2197
SIDM00340	MM\|myeloma	p.A11P (No)	GDSC	Lestaurtinib	15.4612
SIDM00340	MM\|myeloma	p.A11P (No)	GDSC	AZD1332	30.6287
SIDM00340	MM\|myeloma	p.A11P (No)	GDSC	AZD1332	769.33
SIDM00371	PAAD\|pancreas	p.K312N (No)	GDSC	WZ3105	30.962
SIDM00371	PAAD\|pancreas	p.K312N (No)	GDSC	Lestaurtinib	0.3642
SIDM00371	PAAD\|pancreas	p.K312N (No)	GDSC	AZD1332	9.4477
SIDM00371	PAAD\|pancreas	p.K312N (No)	GDSC	AZD1332	930.29
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.W20C (No)	GDSC	WZ3105	0.305
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.W20C (No)	GDSC	Lestaurtinib	0.1254
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.W20C (No)	GDSC	AZD1332	20.9135
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.W20C (No)	GDSC	AZD1332	10.823
SIDM00120	PRAD\|prostate	p.K599N (No)	GDSC	WZ3105	5.5969
SIDM00120	PRAD\|prostate	p.K599N (No)	GDSC	Lestaurtinib	1.5774
SIDM00120	PRAD\|prostate	p.K599N (No)	GDSC	AZD1332	9.973
SIDM00120	PRAD\|prostate	p.K599N (No)	GDSC	AZD1332	499.93
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K767* (No)	GDSC	WZ3105	40.7427
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K767* (No)	GDSC	Lestaurtinib	6.3969
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.K767* (No)	GDSC	AZD1332	4.844
SIDM00114	MESO\|mesothelioma	p.G321W (No)	GDSC	WZ3105	2.8231
SIDM00114	MESO\|mesothelioma	p.G321W (No)	GDSC	Lestaurtinib	56.2713
SIDM00114	MESO\|mesothelioma	p.G321W (No)	GDSC	AZD1332	7.9442
SIDM00114	MESO\|mesothelioma	p.G321W (No)	GDSC	AZD1332	448.39
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.V53M (No)	GDSC	WZ3105	0.1088
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.V53M (No)	GDSC	Lestaurtinib	0.697
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.V53M (No)	GDSC	AZD1332	16.949
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.V53M (No)	GDSC	AZD1332	22.733
SIDM00225	SKCM\|melanoma	p.D421G (No)	GDSC	WZ3105	0.6975
SIDM00225	SKCM\|melanoma	p.D421G (No)	GDSC	Lestaurtinib	0.257
SIDM00225	SKCM\|melanoma	p.D421G (No)	GDSC	AZD1332	5.412
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.P474L (No)	GDSC	WZ3105	0.3031
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.P474L (No)	GDSC	Lestaurtinib	0.846
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.P474L (No)	GDSC	AZD1332	38.7505
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.P474L (No)	GDSC	AZD1332	109.95
SIDM00986	HNSC\|head_and_neck	p.L584F (No)	GDSC	WZ3105	1.5806
SIDM00986	HNSC\|head_and_neck	p.L584F (No)	GDSC	Lestaurtinib	0.6508
SIDM00986	HNSC\|head_and_neck	p.L584F (No)	GDSC	AZD1332	7.7295
SIDM00080	SKCM\|melanoma	p.P185L (No)	GDSC	WZ3105	1.3131
SIDM00080	SKCM\|melanoma	p.P185L (No)	GDSC	Lestaurtinib	0.2275
SIDM00080	SKCM\|melanoma	p.P185L (No)	GDSC	AZD1332	20.945
SIDM00080	SKCM\|melanoma	p.P185L (No)	GDSC	AZD1332	185.34
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.W230L (No)	GDSC	WZ3105	0.6886
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.W230L (No)	GDSC	Lestaurtinib	2.2455
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.W230L (No)	GDSC	AZD1332	6.252
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.W230L (No)	GDSC	AZD1332	31.982
SIDM01259	ALL\|lymphoblastic_leukemia	p.I334R (No)	GDSC	WZ3105	0.1401
SIDM01259	ALL\|lymphoblastic_leukemia	p.I334R (No)	GDSC	Lestaurtinib	0.2633
SIDM01259	ALL\|lymphoblastic_leukemia	p.I334R (No)	GDSC	AZD1332	9.2278
SIDM01259	ALL\|lymphoblastic_leukemia	p.I334R (No)	GDSC	AZD1332	295.56
SIDM00920	BRCA\|breast	p.P661A (No)	GDSC	WZ3105	0.6648
SIDM00920	BRCA\|breast	p.P661A (No)	GDSC	Lestaurtinib	1.3536
SIDM00920	BRCA\|breast	p.P661A (No)	GDSC	AZD1332	22.6233
SIDM00920	BRCA\|breast	p.P661A (No)	GDSC	AZD1332	238.97
SIDM00284	SKCM\|melanoma	p.D835H (No)	GDSC	WZ3105	0.8719
SIDM00284	SKCM\|melanoma	p.D835H (No)	GDSC	Lestaurtinib	0.4299
SIDM00284	SKCM\|melanoma	p.D835H (No)	GDSC	AZD1332	33.6704
SIDM00284	SKCM\|melanoma	p.D835H (No)	GDSC	AZD1332	398.61
SIDM00193	COREAD\|large_intestine	p.F150C (No)	GDSC	WZ3105	0.4941
SIDM00193	COREAD\|large_intestine	p.F150C (No)	GDSC	Lestaurtinib	1.9368
SIDM00193	COREAD\|large_intestine	p.F150C (No)	GDSC	AZD1332	8.82
SIDM00193	COREAD\|large_intestine	p.F150C (No)	GDSC	AZD1332	125.9
SIDM00118	COREAD\|large_intestine	p.F467L (No)	GDSC	WZ3105	0.4527
SIDM00118	COREAD\|large_intestine	p.F467L (No)	GDSC	Lestaurtinib	3.0943
SIDM00118	COREAD\|large_intestine	p.F467L (No)	GDSC	AZD1332	7.5922
SIDM00118	COREAD\|large_intestine	p.F467L (No)	GDSC	AZD1332	13.859

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGKQIS

Degron related mutations and impact score

Drug responses associated with NTRK2 mutations

All proteins holding degron of DSGKQIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16620	BDNF/NT-3 growth factors receptor	DEG_SCF_TRCP1_1	259:265	DSGKQIS	BTRC	0.9478	More...