FUNCTION: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-i...
FUNCTION: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269|PubMed:21693781}.
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GO - Biological processes (BP):
inflammatory response [GO:0006954]; toxin transport [GO:1901998]...
inflammatory response [GO:0006954]; toxin transport [GO:1901998]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]...
identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; meprin A complex [GO:0017090]...
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; meprin A complex [GO:0017090]
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