DegronMD

Uniprot ID: Q16820

Source protein: Meprin A subunit beta

Source gene: MEP1B

Class: DEG_SCF_FBW7_1

Location: 596:603

E3 ligase: FBXW7

DEGRON score: 0.7334

ASA_SCORE: 77.9375

COIL: 0.91

CONS_SCORE: 0.4128

DSS_SCORE: 0.2262

HELIX: 0.0305

FCONS_SCORE: 0.9119

RIG_SCORE: 0.7778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L607F	TCGA-D3-A51R	SKCM	TCGA	IQLTPAPS	DEG_SCF_FBW7_1	0.2222
p.L607F	DO47480	SKCM	ICGC	IQLTPAPS	DEG_SCF_FBW7_1	0.2222
p.D606V	DO233819	GACA	ICGC	IQLTPAPS	DEG_SCF_FBW7_1	0.25
p.V604F	DO229027	LICA	ICGC	IQLTPAPS	DEG_SCF_FBW7_1	0.3056
p.A601T	DO220877	MELA	ICGC	IQLTPAPS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16820	Meprin A subunit beta	DEG_SCF_FBW7_1	596:603	IQLTPAPS	FBXW7	0.7334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons