DegronMD - Q16821(PPP1R3A)

PPP1R3A

UniProt ID: Q16821

Entrez ID: 5506

Protein name: Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L369V	TCGA-A5-A0G2	UCEC	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1944
p.L369V	DO41235	UCEC	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1944
p.T367A	TCGA-B5-A3FC	UCEC	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.25
p.T367A	DO41871	UCEC	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.25
p.F370L	TCGA-D3-A2JP	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1667
p.F370L	DO47407	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1667
p.P350S	TCGA-D9-A4Z3	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350S	TCGA-ER-A193	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350S	TCGA-GN-A8LK	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350S	DO47368	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350S	DO47555	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350S	DO51259	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.R372K	TCGA-EE-A3AA	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.R372K	DO222632	MELA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.R372K	DO37571	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350L	TCGA-EE-A3JD	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350L	TCGA-WS-AB45	COAD	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350L	DO51734	COAD	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.P350L	DO50299	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.1111
p.L356V	TCGA-L5-A8NF	ESCA	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.H362Y	TCGA-WE-A8K4	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation altering degron motif	0.6118
p.H362Y	DO51281	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation altering degron motif	0.6118
p.Q360P	DO234289	ESAD	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation altering degron motif	0.5924
p.S373F	DO45153	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.0833
p.S373F	DO232224	PBCA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.0833
p.G355V	DO45173	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.25
p.G355W	DO45173	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.25
p.H362R	DO232224	PBCA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation altering degron motif	0.8244
p.I365M	SIDM00238	Ovarian Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.3056
p.I365M	ACH-000947	Ovarian Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.3056
p.I365M	OVK-18	ovary	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.3056
p.L356F	SIDM00562	Breast Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	ACH-000855	Esophageal Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	ACH-002163	Breast Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	MRK-nu-1	breast	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	SW1573	lung	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778
p.L356F	KYSE-150	oesophagus	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	358:364	Mutation rewiring degron network	0.2778

Kaplan plot for PPP1R3A in

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*NOTE: the Kaplan plots were collected from OncoLnc