DegronMD

Uniprot ID: Q16821

Source protein: Protein phosphatase 1 regulatory subunit 3A

Source gene: PPP1R3A

Class: LIG_APCC_ABBAyCdc20_2

Location: 358:364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7656

ASA_SCORE: 104.5857

COIL: 0.7459

CONS_SCORE: 0.4147

DSS_SCORE: 0.4087

HELIX: 0.1626

FCONS_SCORE: 0.8409

RIG_SCORE: 0.7764

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L369V	TCGA-A5-A0G2	UCEC	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L369V	DO41235	UCEC	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T367A	TCGA-B5-A3FC	UCEC	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.T367A	DO41871	UCEC	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.F370L	TCGA-D3-A2JP	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F370L	DO47407	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P350S	TCGA-D9-A4Z3	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350S	TCGA-ER-A193	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350S	TCGA-GN-A8LK	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350S	DO47368	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350S	DO47555	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350S	DO51259	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R372K	TCGA-EE-A3AA	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R372K	DO222632	MELA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R372K	DO37571	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350L	TCGA-EE-A3JD	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350L	TCGA-WS-AB45	COAD	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350L	DO51734	COAD	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P350L	DO50299	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L356V	TCGA-L5-A8NF	ESCA	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H362Y	TCGA-WE-A8K4	SKCM	TCGA	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H362Y	DO51281	SKCM	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Q360P	DO234289	ESAD	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.5924
p.S373F	DO45153	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S373F	DO232224	PBCA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G355V	DO45173	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.G355W	DO45173	LIRI	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.25
p.H362R	DO232224	PBCA	ICGC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.8244
p.I365M	SIDM00238	Ovarian Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I365M	ACH-000947	Ovarian Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I365M	OVK-18	ovary	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L356F	SIDM00562	Breast Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	ACH-000855	Esophageal Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	ACH-002163	Breast Cancer	CCLE	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	MRK-nu-1	breast	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	SW1573	lung	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L356F	KYSE-150	oesophagus	COSMIC	KKQIHGE	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKQIHGE

Degron related mutations and impact score

Drug responses associated with PPP1R3A mutations

All proteins holding degron of KKQIHGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16821	Protein phosphatase 1 regulatory subunit 3A	LIG_APCC_ABBAyCdc20_2	358:364	KKQIHGE	APC,CDC20,FZR1	0.7656	More...