DegronMD - Q16828(DUSP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D93N	TCGA-AA-3984	COAD	TCGA	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.2778
p.D93N	DO9002	COAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.2778
p.R85L	TCGA-CN-6992	HNSC	TCGA	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.0556
p.R85L	DO14606	HNSC	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.0556
p.R88L	TCGA-EM-A22J	THCA	TCGA	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1389
p.R88L	DO39096	THCA	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1389
p.T87I	DO234285	ESAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1111
p.D101E	DO229037	LICA	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.3056
p.F106L	DO229008	LICA	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1667
p.I108N	DO45339	LUAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1111
p.V102M	DO228736	PRAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.2778
p.R85C	DO229259	THCA	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.0556
p.P87S	DO43306	UCEC	ICGC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.1111
p.E100K	SIDM00003	Melanoma	GDSC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation altering degron motif	0.7022
p.E100K	ACH-002159	Skin Cancer	CCLE	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation altering degron motif	0.7022
p.Y110C	SNU-C5	large intestine	COSMIC	VVLYDE	LIG_APCC_ABBA_1	95:100	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons