DegronMD

Uniprot ID: Q16828

Source protein: Dual specificity protein phosphatase 6

Source gene: DUSP6

Class: LIG_APCC_ABBA_1

Location: 95:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5729

ASA_SCORE: 14.65

COIL: 0.275

CONS_SCORE: 0.4687

DSS_SCORE: 0.3181

HELIX: 0.0147

FCONS_SCORE: 1.5931

RIG_SCORE: 0.845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D93N	TCGA-AA-3984	COAD	TCGA	VVLYDE	LIG_APCC_ABBA_1	0.2778
p.D93N	DO9002	COAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.2778
p.R85L	TCGA-CN-6992	HNSC	TCGA	VVLYDE	LIG_APCC_ABBA_1	0.0556
p.R85L	DO14606	HNSC	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.0556
p.R88L	TCGA-EM-A22J	THCA	TCGA	VVLYDE	LIG_APCC_ABBA_1	0.1389
p.R88L	DO39096	THCA	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.1389
p.T87I	DO234285	ESAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.1111
p.D101E	DO229037	LICA	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.3056
p.F106L	DO229008	LICA	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.1667
p.I108N	DO45339	LUAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.1111
p.V102M	DO228736	PRAD	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.2778
p.R85C	DO229259	THCA	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.0556
p.P87S	DO43306	UCEC	ICGC	VVLYDE	LIG_APCC_ABBA_1	0.1111
p.E100K	SIDM00003	Melanoma	GDSC	VVLYDE	LIG_APCC_ABBA_1	0.7022
p.E100K	ACH-002159	Skin Cancer	CCLE	VVLYDE	LIG_APCC_ABBA_1	0.7022
p.Y110C	SNU-C5	large_intestine	COSMIC	VVLYDE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16828	Dual specificity protein phosphatase 6	LIG_APCC_ABBA_1	95:100	VVLYDE	APC,CDC20,FZR1	0.5729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons