DegronMD - Q16849(PTPRN)

FUNCTION: Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L142S	TCGA-2Y-A9GT	LIHC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.7667
p.L142S	DO219506	LIHC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.7667
p.A130T	TCGA-B5-A0JZ	UCEC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.7139
p.A130T	DO42761	UCEC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.7139
p.S127F	TCGA-EO-A22U	UCEC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.2778
p.S127F	DO43755	UCEC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.2778
p.A150T	TCGA-UE-A6QU	SARC	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111
p.A150T	DO220285	SARC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111
p.R126M	TCGA-VQ-A91D	STAD	TCGA	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.25
p.R126M	DO51783	STAD	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.25
p.G135C	DO52393	LIHM	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.6489
p.K132Q	DO52393	LIHM	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.5833
p.A150P	DO23108	LINC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111
p.A150P	DO45041	LINC	ICGC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1111
p.Q143H	SIDM00373	Endometrial Carcinoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.3056
p.Q143H	ACH-000974	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.3056
p.Q143H	ACH-002026	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.3056
p.Q143H	SNG-M	endometrium	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.3056
p.R122H	SIDM00845	Burkitt's Lymphoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1389
p.R122H	SIDM01206	Neuroblastoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1389
p.R122H	ACH-000310	Neuroblastoma	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1389
p.R122H	ACH-002248	Neuroblastoma	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1389
p.R122H	IMR-5	autonomic ganglia	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1389
p.K132R	SIDM00198	Ewing's Sarcoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.6126
p.S127Y	SIDM01470	Acute Myeloid Leukemia	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.2778
p.S127Y	ACH-000387	Leukemia	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.2778
p.R133I	SIDM01588	Endometrial Carcinoma	GDSC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.6991
p.R133I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation altering degron motif	0.6991
p.G148A	ACH-000886	Lung Cancer	CCLE	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1667
p.G148A	NCI-H2009	lung	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.1667
p.R127H	CCF-STTG1	central nervous system	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.2778
p.P151L	LU-165	lung	COSMIC	LAPKRPGPAGELLL	DEG_ODPH_VHL_1	129:142	Mutation rewiring degron network	0.0833

Kaplan plot for PTPRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRN

UniProt ID: Q16849

Entrez ID: 5798

Protein name: Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRN in